Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 1768732..1769334 Replicon chromosome
Accession NZ_CP085812
Organism Salmonella enterica subsp. enterica serovar Schwarzengrund strain Articuno

Toxin (Protein)


Gene name higB Uniprot ID A0A3V8XMR3
Locus tag LJF40_RS08325 Protein ID WP_001159631.1
Coordinates 1768732..1769043 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LJF40_RS08330 Protein ID WP_000362050.1
Coordinates 1769044..1769334 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF40_RS08290 (LJF40_08290) 1763845..1764444 + 600 WP_000965695.1 glucose-1-phosphatase -
LJF40_RS08295 (LJF40_08295) 1764438..1765310 + 873 WP_000921423.1 virulence factor BrkB family protein -
LJF40_RS08300 (LJF40_08300) 1765307..1765744 + 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
LJF40_RS08305 (LJF40_08305) 1765789..1766730 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
LJF40_RS08310 (LJF40_08310) 1766745..1767191 - 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
LJF40_RS08315 (LJF40_08315) 1767188..1767499 - 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
LJF40_RS08320 (LJF40_08320) 1767585..1768514 - 930 WP_001127691.1 alpha/beta hydrolase -
LJF40_RS08325 (LJF40_08325) 1768732..1769043 + 312 WP_001159631.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
LJF40_RS08330 (LJF40_08330) 1769044..1769334 + 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
LJF40_RS08335 (LJF40_08335) 1769381..1770310 - 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
LJF40_RS08340 (LJF40_08340) 1770307..1770942 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
LJF40_RS08345 (LJF40_08345) 1770939..1771841 - 903 WP_000331364.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12312.25 Da        Isoelectric Point: 9.4460

>T221788 WP_001159631.1 NZ_CP085812:1768732-1769043 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEVRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T221788 NZ_CP117590:c2552437-2552282 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGGCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT221788 WP_000362050.1 NZ_CP085812:1769044-1769334 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT221788 NZ_CP117590:2552449-2552507 [Escherichia albertii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V8XMR3

Antitoxin

Source ID Structure

References