Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 434238..435019 | Replicon | chromosome |
| Accession | NZ_CP085809 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain Raikou | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | Q8Z1M4 |
| Locus tag | LJF43_RS02040 | Protein ID | WP_000626103.1 |
| Coordinates | 434528..435019 (+) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | Q8Z1M5 |
| Locus tag | LJF43_RS02035 | Protein ID | WP_001110456.1 |
| Coordinates | 434238..434531 (+) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJF43_RS02005 (LJF43_02005) | 430491..431396 | + | 906 | WP_001268195.1 | YjiK family protein | - |
| LJF43_RS02010 (LJF43_02010) | 431683..432027 | - | 345 | WP_100680417.1 | Ig-like domain-containing protein | - |
| LJF43_RS02015 (LJF43_02015) | 432035..432251 | - | 217 | Protein_383 | hypothetical protein | - |
| LJF43_RS02020 (LJF43_02020) | 432274..432561 | - | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| LJF43_RS02025 (LJF43_02025) | 432558..433433 | - | 876 | WP_000921674.1 | AraC family transcriptional regulator | - |
| LJF43_RS02030 (LJF43_02030) | 433699..433921 | - | 223 | Protein_386 | hypothetical protein | - |
| LJF43_RS02035 (LJF43_02035) | 434238..434531 | + | 294 | WP_001110456.1 | DUF1778 domain-containing protein | Antitoxin |
| LJF43_RS02040 (LJF43_02040) | 434528..435019 | + | 492 | WP_000626103.1 | GNAT family N-acetyltransferase | Toxin |
| LJF43_RS02045 (LJF43_02045) | 435260..436012 | - | 753 | WP_001785756.1 | non-specific acid phosphatase | - |
| LJF43_RS02050 (LJF43_02050) | 436112..436189 | - | 78 | Protein_390 | porin family protein | - |
| LJF43_RS02055 (LJF43_02055) | 436569..436643 | + | 75 | Protein_391 | helix-turn-helix domain-containing protein | - |
| LJF43_RS02060 (LJF43_02060) | 436857..437891 | + | 1035 | WP_001195363.1 | ParA family protein | - |
| LJF43_RS02065 (LJF43_02065) | 437888..439252 | + | 1365 | WP_000018529.1 | SPI-7-type island replicative DNA helicase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | sopE2 / vexE / vexD / vexC / vexB / vexA / tviE / tviD / tviC / tviB | 323342..563237 | 239895 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17675.47 Da Isoelectric Point: 7.2652
>T221734 WP_000626103.1 NZ_CP085809:434528-435019 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQWVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQWVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
>T221734 NZ_CP117580:693631-694008 [Escherichia albertii]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCATTTGTCCCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAATGGTAAATAACATTACCCAGGGTAAGCATCCGGAGGCGCAACAATGA
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCATTTGTCCCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAATGGTAAATAACATTACCCAGGGTAAGCATCCGGAGGCGCAACAATGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 11005.67 Da Isoelectric Point: 8.6141
>AT221734 WP_001110456.1 NZ_CP085809:434238-434531 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEVLIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEVLIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
>AT221734 NZ_CP117580:693173-693541 [Escherichia albertii]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCAGATGCATACCACCTGGACCAGGCCTTTGCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCAGATGCATACCACCTGGACCAGGCCTTTGCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A718CB38 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A716NSU2 |