Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1217288..1217908 Replicon chromosome
Accession NZ_CP085803
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Glaceon

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LJF50_RS05710 Protein ID WP_001280991.1
Coordinates 1217288..1217506 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LJF50_RS05715 Protein ID WP_000344807.1
Coordinates 1217534..1217908 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF50_RS05670 (1212511) 1212511..1213080 + 570 WP_000779802.1 YbaY family lipoprotein -
LJF50_RS05675 (1213113) 1213113..1213502 - 390 WP_000961287.1 MGMT family protein -
LJF50_RS05685 (1213733) 1213733..1215283 - 1551 WP_000213140.1 EAL domain-containing protein -
LJF50_RS05690 (1215508) 1215508..1215768 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LJF50_RS05695 (1215774) 1215774..1215914 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LJF50_RS05700 (1215970) 1215970..1216440 - 471 WP_000136183.1 YlaC family protein -
LJF50_RS05705 (1216558) 1216558..1217109 - 552 WP_001278793.1 maltose O-acetyltransferase -
LJF50_RS05710 (1217288) 1217288..1217506 - 219 WP_001280991.1 HHA domain-containing protein Toxin
LJF50_RS05715 (1217534) 1217534..1217908 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LJF50_RS05720 (1218404) 1218404..1221553 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LJF50_RS05725 (1221576) 1221576..1222769 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T221599 WP_001280991.1 NZ_CP085803:c1217506-1217288 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T221599 NZ_CP117526:215900-216223 [Fusobacterium nucleatum]
GTGGTAAAAAGAGGAGATATTATTATAATAAATTTTAATCCTGTAAAAGGGCATGAGCAAGCAGGTAAAAGACCAGCATT
AGTTATCAGTAATGAAAAATTTTATAAAATATTTAAATTAGCAGTAATTCTTCCAATAACAAACAATACAAAAGATTTTC
CATTTCATGTATTATTAGATGAAAGAACAAATATAAAAGGTGCAATATTATGTGAACATTTAAGAACAGTTGATTTAGAA
GAAAGAAAATATGATAAGATTGAAGAGATACCAGAAGATTTGTTAGAAGAAGTACTTGAAAAAGTAAGTTTAATTTTTCA
ATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT221599 WP_000344807.1 NZ_CP085803:c1217908-1217534 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT221599 NZ_CP117526:215652-215906 [Fusobacterium nucleatum]
ATGGAAGTGTTAAGAGTTCAGAAATGGGGAAATAGCCAAGGAATAAGATTACCAAAAAAAATTTTAAAAGATTTAGGGAT
AGATGTAAATGATAAAATAGAAATTAGCTTGAATGATGGAGAAATTATATTAAGAAAAGTAAAAAAATATATTGATTTAG
ATGATTTATTTAAAGATTATAAAGGAGATTATAGGGAAGATTTTGCTGAATTTGAGTTTTTTGGAGAGGCACAAGGTCGT
GAATTTAAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References