Detailed information of TA system TA221591

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 140259..140861
• Replicon: chromosome
• Accession: NZ_CP085803
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Glaceon

Toxin (Protein)

• Gene name: higB
• Uniprot ID: M7S4R6
• Locus tag: LJF50_RS00705
• Protein ID: WP_001159635.1
• Coordinates: 140259..140570 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LJF50_RS00710
• Protein ID: WP_000362050.1
• Coordinates: 140571..140861 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF50_RS00670 (135372)	135372..135971	+	600	WP_000965695.1	glucose-1-phosphatase	-
LJF50_RS00675 (135965)	135965..136837	+	873	WP_000921423.1	virulence factor BrkB family protein	-
LJF50_RS00680 (136834)	136834..137271	+	438	WP_000560968.1	D-aminoacyl-tRNA deacylase	-
LJF50_RS00685 (137316)	137316..138257	+	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
LJF50_RS00690 (138272)	138272..138718	-	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
LJF50_RS00695 (138715)	138715..139026	-	312	WP_000558168.1	type II toxin-antitoxin system HigB family toxin	-
LJF50_RS00700 (139112)	139112..140041	-	930	WP_001127705.1	alpha/beta hydrolase	-
LJF50_RS00705 (140259)	140259..140570	+	312	WP_001159635.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
LJF50_RS00710 (140571)	140571..140861	+	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
LJF50_RS00715 (140908)	140908..141837	-	930	WP_000027736.1	formate dehydrogenase accessory protein FdhE	-
LJF50_RS00720 (141834)	141834..142469	-	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
LJF50_RS00725 (142466)	142466..143368	-	903	WP_000331364.1	formate dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12340.30 Da
• Isoelectric Point: 9.4460

>T221591 WP_001159635.1 NZ_CP085803:140259-140570 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T221591 NZ_CP117511:2698364-2698507 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGAAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT221591 WP_000362050.1 NZ_CP085803:140571-140861 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT221591 NZ_CP117511:c2698267-2698066 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A3V2JK97