Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4060417..4061171 Replicon chromosome
Accession NZ_CP085798
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Latias

Toxin (Protein)


Gene name higB Uniprot ID B5RFE2
Locus tag LJF55_RS19840 Protein ID WP_000558168.1
Coordinates 4060417..4060728 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LJF55_RS19845 Protein ID WP_001259009.1
Coordinates 4060725..4061171 (+) Length 149 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF55_RS19810 (4056075) 4056075..4056977 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
LJF55_RS19815 (4056974) 4056974..4057609 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
LJF55_RS19820 (4057606) 4057606..4058535 + 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
LJF55_RS19825 (4058582) 4058582..4058872 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
LJF55_RS19830 (4058873) 4058873..4059184 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system -
LJF55_RS19835 (4059402) 4059402..4060331 + 930 WP_001127705.1 alpha/beta hydrolase -
LJF55_RS19840 (4060417) 4060417..4060728 + 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin Toxin
LJF55_RS19845 (4060725) 4060725..4061171 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
LJF55_RS19850 (4061186) 4061186..4062127 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
LJF55_RS19855 (4062172) 4062172..4062609 - 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
LJF55_RS19860 (4062606) 4062606..4063478 - 873 WP_000921423.1 virulence factor BrkB family protein -
LJF55_RS19865 (4063472) 4063472..4064071 - 600 WP_000965695.1 glucose-1-phosphatase -
LJF55_RS19870 (4064262) 4064262..4065065 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
LJF55_RS19875 (4065099) 4065099..4065995 - 897 WP_001520529.1 sugar kinase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12324.26 Da        Isoelectric Point: 9.3143

>T221482 WP_000558168.1 NZ_CP085798:4060417-4060728 [Salmonella enterica subsp. enterica serovar Enteritidis]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE

Download         Length: 312 bp

>T221482 NZ_CP117398:c4173401-4173114 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT221482 WP_001259009.1 NZ_CP085798:4060725-4061171 [Salmonella enterica subsp. enterica serovar Enteritidis]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT221482 NZ_CP117398:c4173127-4172825 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A1R2S541


Antitoxin

Source ID Structure

References