Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3642235..3642751 Replicon chromosome
Accession NZ_CP085798
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Latias

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag LJF55_RS17905 Protein ID WP_000220582.1
Coordinates 3642235..3642519 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag LJF55_RS17910 Protein ID WP_000212724.1
Coordinates 3642509..3642751 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF55_RS17890 (3637446) 3637446..3639098 + 1653 WP_000155048.1 alpha,alpha-phosphotrehalase -
LJF55_RS17895 (3639507) 3639507..3641645 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
LJF55_RS17900 (3641767) 3641767..3642231 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LJF55_RS17905 (3642235) 3642235..3642519 - 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJF55_RS17910 (3642509) 3642509..3642751 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LJF55_RS17915 (3642829) 3642829..3644742 - 1914 WP_001212142.1 BglG family transcription antiterminator -
LJF55_RS17920 (3644759) 3644759..3645499 - 741 WP_000779259.1 KDGP aldolase family protein -
LJF55_RS17925 (3645496) 3645496..3646614 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LJF55_RS17930 (3646598) 3646598..3647731 - 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T221479 WP_000220582.1 NZ_CP085798:c3642519-3642235 [Salmonella enterica subsp. enterica serovar Enteritidis]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T221479 NZ_CP117398:2475403-2475687 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT221479 WP_000212724.1 NZ_CP085798:c3642751-3642509 [Salmonella enterica subsp. enterica serovar Enteritidis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT221479 NZ_CP117398:2475165-2475413 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References