Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3601110..3601660 Replicon chromosome
Accession NZ_CP085798
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Latias

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag LJF55_RS17685 Protein ID WP_001199743.1
Coordinates 3601110..3601418 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag LJF55_RS17690 Protein ID WP_001118105.1
Coordinates 3601421..3601660 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF55_RS17665 (3597684) 3597684..3598424 - 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -
LJF55_RS17670 (3598546) 3598546..3599076 - 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
LJF55_RS17675 (3599399) 3599399..3600532 + 1134 Protein_3450 IS3 family transposase -
LJF55_RS17680 (3600564) 3600564..3600704 - 141 Protein_3451 Arm DNA-binding domain-containing protein -
LJF55_RS17685 (3601110) 3601110..3601418 - 309 WP_001199743.1 CcdB family protein Toxin
LJF55_RS17690 (3601421) 3601421..3601660 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LJF55_RS17695 (3601769) 3601769..3602017 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
LJF55_RS17700 (3602094) 3602094..3602639 - 546 WP_223151225.1 helix-turn-helix domain-containing protein -
LJF55_RS17715 (3603396) 3603396..3604415 + 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
LJF55_RS17720 (3604443) 3604443..3604973 - 531 WP_000896758.1 gluconokinase -
LJF55_RS17725 (3605190) 3605190..3606221 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 3599491..3602594 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T221478 WP_001199743.1 NZ_CP085798:c3601418-3601110 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T221478 NZ_CP117398:2134094-2134197 [Salmonella enterica subsp. enterica serovar Typhimurium]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT221478 WP_001118105.1 NZ_CP085798:c3601660-3601421 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT221478 NZ_CP117398:c2134199-2134054 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References