Detailed information of TA system TA221456

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 4505105..4505725
• Replicon: chromosome
• Accession: NZ_CP085797
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Latios

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: LJF56_RS21940
• Protein ID: WP_001280991.1
• Coordinates: 4505507..4505725 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: LJF56_RS21935
• Protein ID: WP_000344807.1
• Coordinates: 4505105..4505479 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF56_RS21925 (4500244)	4500244..4501437	+	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
LJF56_RS21930 (4501460)	4501460..4504609	+	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
LJF56_RS21935 (4505105)	4505105..4505479	+	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
LJF56_RS21940 (4505507)	4505507..4505725	+	219	WP_001280991.1	HHA domain-containing protein	Toxin
LJF56_RS21945 (4505904)	4505904..4506455	+	552	WP_001278793.1	maltose O-acetyltransferase	-
LJF56_RS21950 (4506573)	4506573..4507043	+	471	WP_000136183.1	YlaC family protein	-
LJF56_RS21955 (4507099)	4507099..4507239	-	141	WP_001197749.1	type B 50S ribosomal protein L36	-
LJF56_RS21960 (4507245)	4507245..4507505	-	261	WP_000801415.1	type B 50S ribosomal protein L31	-
LJF56_RS21965 (4507730)	4507730..4509280	+	1551	WP_000213140.1	EAL domain-containing protein	-
LJF56_RS21975 (4509511)	4509511..4509900	+	390	WP_000961287.1	MGMT family protein	-
LJF56_RS21980 (4509933)	4509933..4510502	-	570	WP_000779802.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T221456 WP_001280991.1 NZ_CP085797:4505507-4505725 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T221456 NZ_CP117396:188850-189335 [Salmonella enterica subsp. enterica serovar Uganda]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT221456 WP_000344807.1 NZ_CP085797:4505105-4505479 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT221456 NZ_CP117396:188575-188862 [Salmonella enterica subsp. enterica serovar Uganda]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCAGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0