Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VapB |
Location | 754290..754923 | Replicon | chromosome |
Accession | NC_009525 | ||
Organism | Mycobacterium tuberculosis H37Ra |
Toxin (Protein)
Gene name | vapC | Uniprot ID | G0TQD6 |
Locus tag | MRA_RS03465 | Protein ID | WP_003403365.1 |
Coordinates | 754290..754673 (-) | Length | 128 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | P9WJ56 |
Locus tag | MRA_RS03470 | Protein ID | WP_003403368.1 |
Coordinates | 754768..754923 (-) | Length | 52 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MRA_RS03440 | 749582..750118 | + | 537 | WP_003403341.1 | 50S ribosomal protein L10 | - |
MRA_RS03445 | 750155..750547 | + | 393 | WP_003403353.1 | 50S ribosomal protein L7/L12 | - |
MRA_RS03450 | 750540..751235 | - | 696 | WP_003403355.1 | TetR/AcrR family transcriptional regulator | - |
MRA_RS03455 | 751306..752811 | + | 1506 | WP_003403360.1 | carotenoid cleavage oxygenase | - |
MRA_RS03460 | 752892..753902 | + | 1011 | WP_003911248.1 | ABC transporter ATP-binding protein | - |
MRA_RS03465 | 754290..754673 | - | 384 | WP_003403365.1 | ribonuclease VapC6 | Toxin |
MRA_RS03470 | 754768..754923 | - | 156 | WP_003403368.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
MRA_RS03475 | 754999..755715 | - | 717 | WP_003403371.1 | CPBP family intramembrane metalloprotease | - |
MRA_RS03480 | 755991..756299 | - | 309 | WP_003403376.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
MRA_RS03485 | 756286..756531 | - | 246 | WP_003403381.1 | ribbon-helix-helix protein, CopG family | - |
MRA_RS03490 | 756641..757078 | - | 438 | WP_003403386.1 | type II toxin-antitoxin system VapC family toxin | - |
MRA_RS03495 | 757075..757329 | - | 255 | WP_003911263.1 | antitoxin VapB7 | - |
MRA_RS03500 | 757443..759806 | + | 2364 | WP_003898547.1 | arylsulfatase AtsD | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 13959.73 Da Isoelectric Point: 6.0803
>T22145 WP_003403365.1 NC_009525:c754673-754290 [Mycobacterium tuberculosis H37Ra]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD
Download Length: 384 bp
>T22145 NC_009525:c754673-754290 [Mycobacterium tuberculosis H37Ra]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG
Antitoxin
Download Length: 52 a.a. Molecular weight: 5872.72 Da Isoelectric Point: 5.7734
>AT22145 WP_003403368.1 NC_009525:c754923-754768 [Mycobacterium tuberculosis H37Ra]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE
Download Length: 156 bp
>AT22145 NC_009525:c754923-754768 [Mycobacterium tuberculosis H37Ra]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TQD6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BSF8 |