Detailed information of TA system TA221443

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 1884805..1885465
• Replicon: chromosome
• Accession: NZ_CP085797
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Latios

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: Q57K70
• Locus tag: LJF56_RS08890
• Protein ID: WP_000244756.1
• Coordinates: 1885052..1885465 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: S5MU13
• Locus tag: LJF56_RS08885
• Protein ID: WP_000351186.1
• Coordinates: 1884805..1885071 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF56_RS08865 (1880734)	1880734..1882167	-	1434	WP_001230141.1	6-phospho-beta-glucosidase BglA	-
LJF56_RS08870 (1882325)	1882325..1882636	+	312	WP_001182976.1	N(4)-acetylcytidine aminohydrolase	-
LJF56_RS08875 (1882800)	1882800..1883459	+	660	WP_000250289.1	hemolysin III family protein	-
LJF56_RS08880 (1883575)	1883575..1884555	-	981	WP_000874176.1	tRNA-modifying protein YgfZ	-
LJF56_RS08885 (1884805)	1884805..1885071	+	267	WP_000351186.1	FAD assembly factor SdhE	Antitoxin
LJF56_RS08890 (1885052)	1885052..1885465	+	414	WP_000244756.1	protein YgfX	Toxin
LJF56_RS08895 (1885518)	1885518..1886039	-	522	WP_001055885.1	flavodoxin FldB	-
LJF56_RS08900 (1886152)	1886152..1887048	+	897	WP_000434302.1	site-specific tyrosine recombinase XerD	-
LJF56_RS08905 (1887072)	1887072..1887785	+	714	WP_000745614.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
LJF56_RS08910 (1887791)	1887791..1889524	+	1734	WP_000813389.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16183.15 Da
• Isoelectric Point: 10.7537

>T221443 WP_000244756.1 NZ_CP085797:1885052-1885465 [Salmonella enterica subsp. enterica serovar Enteritidis]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Nucleotide

• Length: 414 bp

>T221443 NZ_CP117394:c991140-990613 [Salmonella enterica subsp. enterica serovar Uganda]
ATGATGTTTACAGAATGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGCGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATATGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTGTGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10550.05 Da
• Isoelectric Point: 6.0783

>AT221443 WP_000351186.1 NZ_CP085797:1884805-1885071 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT221443 NZ_CP117394:c991427-991137 [Salmonella enterica subsp. enterica serovar Uganda]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Structures

Toxin

• AlphaFold DB: A0A3Z1E9V5

Antitoxin

• AlphaFold DB: A0A5I0YWH4