Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 452402..452918 Replicon chromosome
Accession NZ_CP085797
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Latios

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag LJF56_RS02060 Protein ID WP_000220582.1
Coordinates 452402..452686 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag LJF56_RS02065 Protein ID WP_000212724.1
Coordinates 452676..452918 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF56_RS02045 (447613) 447613..449265 + 1653 WP_000155048.1 alpha,alpha-phosphotrehalase -
LJF56_RS02050 (449674) 449674..451812 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
LJF56_RS02055 (451934) 451934..452398 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LJF56_RS02060 (452402) 452402..452686 - 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJF56_RS02065 (452676) 452676..452918 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LJF56_RS02070 (452996) 452996..454909 - 1914 WP_001212142.1 BglG family transcription antiterminator -
LJF56_RS02075 (454926) 454926..455666 - 741 WP_000779259.1 KDGP aldolase family protein -
LJF56_RS02080 (455663) 455663..456781 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LJF56_RS02085 (456765) 456765..457898 - 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T221436 WP_000220582.1 NZ_CP085797:c452686-452402 [Salmonella enterica subsp. enterica serovar Enteritidis]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T221436 NZ_CP117392:c3990085-3989801 [Salmonella enterica subsp. enterica serovar Give]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCTGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT221436 WP_000212724.1 NZ_CP085797:c452918-452676 [Salmonella enterica subsp. enterica serovar Enteritidis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT221436 NZ_CP117392:c3990317-3990075 [Salmonella enterica subsp. enterica serovar Give]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References