Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 411277..411827 Replicon chromosome
Accession NZ_CP085797
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Latios

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag LJF56_RS01840 Protein ID WP_001199743.1
Coordinates 411277..411585 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag LJF56_RS01845 Protein ID WP_001118105.1
Coordinates 411588..411827 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF56_RS01820 (407851) 407851..408591 - 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -
LJF56_RS01825 (408713) 408713..409243 - 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
LJF56_RS01830 (409566) 409566..410699 + 1134 Protein_357 IS3 family transposase -
LJF56_RS01835 (410731) 410731..410871 - 141 Protein_358 Arm DNA-binding domain-containing protein -
LJF56_RS01840 (411277) 411277..411585 - 309 WP_001199743.1 CcdB family protein Toxin
LJF56_RS01845 (411588) 411588..411827 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LJF56_RS01850 (411936) 411936..412184 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
LJF56_RS01855 (412261) 412261..412806 - 546 WP_223151225.1 helix-turn-helix domain-containing protein -
LJF56_RS01870 (413563) 413563..414582 + 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
LJF56_RS01875 (414610) 414610..415140 - 531 WP_000896758.1 gluconokinase -
LJF56_RS01880 (415357) 415357..416388 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 409658..412761 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T221435 WP_001199743.1 NZ_CP085797:c411585-411277 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T221435 NZ_CP117392:c3949491-3949183 [Salmonella enterica subsp. enterica serovar Give]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGGTTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT221435 WP_001118105.1 NZ_CP085797:c411827-411588 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT221435 NZ_CP117392:c3949733-3949494 [Salmonella enterica subsp. enterica serovar Give]
ATGTCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCTGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTGCTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References