Detailed information of TA system TA221429

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2706545..2706770
• Replicon: chromosome
• Accession: NZ_CP085796
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Froakie

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: LJF57_RS13075
• Protein ID: WP_000813254.1
• Coordinates: 2706615..2706770 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2706545..2706603 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF57_RS13035	2701646..2701867	-	222	WP_000560208.1	cell division protein FtsZ	-
LJF57_RS13040	2702305..2702826	+	522	WP_000004762.1	super-infection exclusion protein B	-
LJF57_RS13045	2702934..2703089	-	156	WP_085981757.1	DUF1391 family protein	-
LJF57_RS13050	2703474..2703941	-	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
LJF57_RS22775	2704123..2704170	+	48	Protein_2531	hypothetical protein	-
LJF57_RS13060	2704214..2704543	+	330	WP_001676916.1	DUF977 family protein	-
LJF57_RS13065	2704705..2705259	-	555	WP_001033796.1	hypothetical protein	-
LJF57_RS13070	2705256..2706188	-	933	WP_000556390.1	hypothetical protein	-
-	2706545..2706603	-	59	-	-	Antitoxin
LJF57_RS13075	2706615..2706770	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
LJF57_RS13080	2707061..2707231	+	171	WP_000734094.1	hypothetical protein	-
LJF57_RS13085	2707294..2707893	+	600	WP_000940751.1	DUF1367 family protein	-
LJF57_RS13090	2707893..2708183	+	291	WP_000774470.1	DUF1364 domain-containing protein	-
LJF57_RS13095	2708180..2708716	+	537	WP_000640113.1	DUF1133 family protein	-
LJF57_RS13100	2710887..2711210	+	324	Protein_2540	tellurite/colicin resistance protein	-
LJF57_RS13105	2711204..2711392	+	189	WP_001688615.1	putative holin	-
LJF57_RS13110	2711382..2711663	+	282	WP_000445513.1	phage holin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2700334..2712205	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T221429 WP_000813254.1 NZ_CP085796:2706615-2706770 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T221429 NZ_CP117391:c14266-13916 [Salmonella enterica subsp. enterica serovar Uganda]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin

Nucleotide

• Length: 59 bp

>AT221429 NZ_CP085796:c2706603-2706545 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin