Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 43863..44617 Replicon chromosome
Accession NZ_CP085793
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Poochyena

Toxin (Protein)


Gene name higB Uniprot ID B5RFE2
Locus tag LJF61_RS00215 Protein ID WP_000558168.1
Coordinates 44306..44617 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LJF61_RS00210 Protein ID WP_001259009.1
Coordinates 43863..44309 (-) Length 149 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF61_RS00180 (39039) 39039..39935 + 897 WP_001520529.1 sugar kinase -
LJF61_RS00185 (39969) 39969..40772 + 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
LJF61_RS00190 (40963) 40963..41562 + 600 WP_000965695.1 glucose-1-phosphatase -
LJF61_RS00195 (41556) 41556..42428 + 873 WP_000921423.1 virulence factor BrkB family protein -
LJF61_RS00200 (42425) 42425..42862 + 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
LJF61_RS00205 (42907) 42907..43848 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
LJF61_RS00210 (43863) 43863..44309 - 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
LJF61_RS00215 (44306) 44306..44617 - 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin Toxin
LJF61_RS00220 (44703) 44703..45632 - 930 WP_001127705.1 alpha/beta hydrolase -
LJF61_RS00225 (45850) 45850..46161 + 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system -
LJF61_RS00230 (46162) 46162..46452 + 291 WP_000362050.1 DNA-binding transcriptional regulator -
LJF61_RS00235 (46499) 46499..47428 - 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
LJF61_RS00240 (47425) 47425..48060 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
LJF61_RS00245 (48057) 48057..48959 - 903 WP_000331364.1 formate dehydrogenase subunit beta -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12324.26 Da        Isoelectric Point: 9.3143

>T221330 WP_000558168.1 NZ_CP085793:c44617-44306 [Salmonella enterica subsp. enterica serovar Enteritidis]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE

Download         Length: 312 bp

>T221330 NZ_CP117378:c991480-990953 [Salmonella enterica subsp. enterica serovar Newport]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGAAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT221330 WP_001259009.1 NZ_CP085793:c44309-43863 [Salmonella enterica subsp. enterica serovar Enteritidis]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT221330 NZ_CP117378:c991767-991477 [Salmonella enterica subsp. enterica serovar Newport]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A1R2S541


Antitoxin

Source ID Structure

References