Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 1233822..1234332 Replicon chromosome
Accession NZ_CP085785
Organism Synechococcus elongatus PCC 6301

Toxin (Protein)


Gene name relB Uniprot ID Q8KPS4
Locus tag PCC6301pg_RS06285 Protein ID WP_011242657.1
Coordinates 1233822..1234085 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q31NY1
Locus tag PCC6301pg_RS06290 Protein ID WP_011242656.1
Coordinates 1234078..1234332 (-) Length 85 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PCC6301pg_RS06260 (PCC6301pg_1260) 1229996..1232446 - 2451 WP_011242661.1 glycosyltransferase family 39 protein -
PCC6301pg_RS06265 (PCC6301pg_1261) 1232534..1232947 - 414 WP_011242660.1 type II toxin-antitoxin system VapC family toxin -
PCC6301pg_RS06270 (PCC6301pg_1262) 1232944..1233186 - 243 WP_190528567.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
PCC6301pg_RS06275 (PCC6301pg_1263) 1233241..1233423 + 183 WP_272948008.1 tyrosine-type recombinase/integrase -
PCC6301pg_RS06280 (PCC6301pg_1264) 1233462..1233695 + 234 WP_231621315.1 DUF2281 domain-containing protein -
PCC6301pg_RS06285 (PCC6301pg_1265) 1233822..1234085 - 264 WP_011242657.1 Txe/YoeB family addiction module toxin Toxin
PCC6301pg_RS06290 (PCC6301pg_1266) 1234078..1234332 - 255 WP_011242656.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
PCC6301pg_RS06295 (PCC6301pg_1267) 1234454..1234714 - 261 WP_011242655.1 DUF2442 domain-containing protein -
PCC6301pg_RS06300 (PCC6301pg_1268) 1234717..1234965 - 249 WP_011377918.1 DUF4160 domain-containing protein -
PCC6301pg_RS06305 (PCC6301pg_1269) 1234965..1235309 - 345 WP_011242653.1 DUF2442 domain-containing protein -
PCC6301pg_RS06310 (PCC6301pg_1270) 1235314..1235574 - 261 WP_011242652.1 DUF4160 domain-containing protein -
PCC6301pg_RS06315 (PCC6301pg_1271) 1235726..1235950 + 225 WP_039755738.1 hypothetical protein -
PCC6301pg_RS06320 (PCC6301pg_1272) 1235954..1236370 + 417 WP_011377919.1 type II toxin-antitoxin system VapC family toxin -
PCC6301pg_RS06325 (PCC6301pg_1273) 1236522..1237004 + 483 WP_173282542.1 glutathione peroxidase -
PCC6301pg_RS06330 (PCC6301pg_1274) 1237030..1238037 + 1008 WP_011377920.1 acyl-CoA dehydrogenase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-85)

Antitoxin

(1-73)


Sequences


Toxin        


Download         Length: 88 a.a.        Molecular weight: 10434.75 Da        Isoelectric Point: 6.9760

>T221299 WP_011242657.1 NZ_CP085785:c1234085-1233822 [Synechococcus elongatus PCC 6301]
MRKLAWTNEAWEDYLYWQGQDKKTLNRINKLITETLRSPFEGIGKPEALRENLTGFWSRRIDDTNRLVYAVADDYLTIIS
CRYHYSD

Download         Length: 264 bp

>T221299 NZ_CP117373:358262-358537 [Salmonella enterica subsp. enterica serovar Dublin]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9478.72 Da        Isoelectric Point: 5.6400

>AT221299 WP_011242656.1 NZ_CP085785:c1234332-1234078 [Synechococcus elongatus PCC 6301]
MKVVSFSDARKNLKTVLDEVVNDADYTIITRRNAEEVVVMSLDSFNSLIETFHLLKSPANAAHLQRSIAQYQQGQTVERN
LLDA

Download         Length: 255 bp

>AT221299 NZ_CP117373:357999-358259 [Salmonella enterica subsp. enterica serovar Dublin]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB Q8KPS4


Antitoxin

Source ID Structure
AlphaFold DB Q31NY1

References