Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 41857..42383 Replicon plasmid p49589CZ_IncFII
Accession NZ_CP085771
Organism Enterobacter hormaechei strain 49589CZ

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag LJU37_RS23020 Protein ID WP_000323025.1
Coordinates 42096..42383 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag LJU37_RS23015 Protein ID WP_004196370.1
Coordinates 41857..42096 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU37_RS22980 (LJU37_22980) 37194..37386 - 193 Protein_45 MFS transporter -
LJU37_RS22985 (LJU37_22985) 37416..38393 + 978 WP_004196334.1 chromate resistance protein -
LJU37_RS22990 (LJU37_22990) 38350..39726 + 1377 WP_004196363.1 chromate efflux transporter -
LJU37_RS22995 (LJU37_22995) 39757..40446 - 690 WP_004196322.1 hypothetical protein -
LJU37_RS23000 (LJU37_23000) 40460..41197 - 738 WP_008460272.1 HupE/UreJ family protein -
LJU37_RS23005 (LJU37_23005) 41241..41606 - 366 WP_009651956.1 hypothetical protein -
LJU37_RS23010 (LJU37_23010) 41734..41832 - 99 Protein_51 protein YdfV -
LJU37_RS23015 (LJU37_23015) 41857..42096 + 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
LJU37_RS23020 (LJU37_23020) 42096..42383 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
LJU37_RS23025 (LJU37_23025) 42531..43871 + 1341 WP_015572075.1 ISNCY family transposase -
LJU37_RS23030 (LJU37_23030) 44091..44267 + 177 WP_154597702.1 hypothetical protein -
LJU37_RS23040 (LJU37_23040) 45723..46034 + 312 WP_015572115.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..130196 130196


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T221265 WP_000323025.1 NZ_CP085771:42096-42383 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T221265 NZ_CP117367:c4772436-4772125 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT221265 WP_004196370.1 NZ_CP085771:41857-42096 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp

>AT221265 NZ_CP117367:c4772124-4771834 [Salmonella enterica subsp. enterica serovar Dublin]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References