Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3072814..3073434 Replicon chromosome
Accession NZ_CP085767
Organism Enterobacter hormaechei strain 49589CZ

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag LJU37_RS14600 Protein ID WP_015571250.1
Coordinates 3072814..3073032 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag LJU37_RS14605 Protein ID WP_006809850.1
Coordinates 3073060..3073434 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU37_RS14570 (LJU37_14570) 3068826..3069086 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
LJU37_RS14575 (LJU37_14575) 3069089..3069229 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LJU37_RS14580 (LJU37_14580) 3069226..3069936 - 711 WP_047051118.1 GNAT family protein -
LJU37_RS14585 (LJU37_14585) 3070038..3071498 + 1461 WP_047051117.1 PLP-dependent aminotransferase family protein -
LJU37_RS14590 (LJU37_14590) 3071470..3071937 - 468 WP_017383209.1 YlaC family protein -
LJU37_RS14595 (LJU37_14595) 3072054..3072605 - 552 WP_017694396.1 maltose O-acetyltransferase -
LJU37_RS14600 (LJU37_14600) 3072814..3073032 - 219 WP_015571250.1 HHA domain-containing protein Toxin
LJU37_RS14605 (LJU37_14605) 3073060..3073434 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
LJU37_RS14610 (LJU37_14610) 3073944..3077090 - 3147 WP_047051116.1 multidrug efflux RND transporter permease subunit AcrB -
LJU37_RS14615 (LJU37_14615) 3077113..3078306 - 1194 WP_047051115.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T221253 WP_015571250.1 NZ_CP085767:c3073032-3072814 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T221253 NZ_CP117367:358319-358594 [Salmonella enterica subsp. enterica serovar Dublin]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT221253 WP_006809850.1 NZ_CP085767:c3073434-3073060 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT221253 NZ_CP117367:358056-358316 [Salmonella enterica subsp. enterica serovar Dublin]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References