Detailed information of TA system TA221249

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 2064894..2065396
• Replicon: chromosome
• Accession: NZ_CP085767
• Organism: Enterobacter hormaechei strain 49589CZ

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: LJU37_RS09825
• Protein ID: WP_047050704.1
• Coordinates: 2065142..2065396 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: LJU37_RS09820
• Protein ID: WP_047050702.1
• Coordinates: 2064894..2065145 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJU37_RS09795 (LJU37_09795)	2060073..2060267	+	195	WP_000644465.1	hypothetical protein	-
LJU37_RS09800 (LJU37_09800)	2060291..2060476	+	186	WP_001196016.1	hypothetical protein	-
LJU37_RS09805 (LJU37_09805)	2060544..2062640	+	2097	WP_227788590.1	peptidase domain-containing ABC transporter	-
LJU37_RS09810 (LJU37_09810)	2062637..2063386	+	750	WP_047050700.1	hypothetical protein	-
LJU37_RS09815 (LJU37_09815)	2063393..2064643	+	1251	WP_047050701.1	HlyD family efflux transporter periplasmic adaptor subunit	-
LJU37_RS09820 (LJU37_09820)	2064894..2065145	+	252	WP_047050702.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
LJU37_RS09825 (LJU37_09825)	2065142..2065396	+	255	WP_047050704.1	Txe/YoeB family addiction module toxin	Toxin
LJU37_RS09830 (LJU37_09830)	2065472..2065627	+	156	WP_154815872.1	hypothetical protein	-
LJU37_RS09835 (LJU37_09835)	2065758..2066846	-	1089	WP_047050706.1	AAA family ATPase	-
LJU37_RS09840 (LJU37_09840)	2066993..2067952	-	960	WP_047050707.1	DUF523 and DUF1722 domain-containing protein	-
LJU37_RS09845 (LJU37_09845)	2068055..2068465	-	411	WP_022650126.1	hydroxyisourate hydrolase	-
LJU37_RS09850 (LJU37_09850)	2068565..2069290	-	726	WP_017383646.1	MerR family transcriptional regulator	-
LJU37_RS09855 (LJU37_09855)	2069408..2069932	+	525	WP_047050709.1	lipocalin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10117.66 Da
• Isoelectric Point: 7.8747

>T221249 WP_047050704.1 NZ_CP085767:2065142-2065396 [Enterobacter hormaechei]
VKITWSEEAWEDYLYWQETDKRMVRKINELIKISCRTPFEGIGKPEPLKHNLAGFWSRRITSEHRMVYAITEEAILIAAC
RYHY

Nucleotide

• Length: 255 bp

>T221249 NZ_CP117365:c4644274-4643963 [Salmonella enterica subsp. enterica serovar Newport]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9343.57 Da
• Isoelectric Point: 4.7854

>AT221249 WP_047050702.1 NZ_CP085767:2064894-2065145 [Enterobacter hormaechei]
MRVISYSEARQNLSATMVQTTEDRAPVLITRQNGESCVLMSLEEYNSLEETAYLMRSPANAKRLMNSIESLKSGSGKERD
IIE

Nucleotide

• Length: 252 bp

>AT221249 NZ_CP117365:c4643962-4643672 [Salmonella enterica subsp. enterica serovar Newport]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA