Detailed information of TA system TA221248

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-MazE
• Location: 2041992..2042648
• Replicon: chromosome
• Accession: NZ_CP085767
• Organism: Enterobacter hormaechei strain 49589CZ

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LJU37_RS09710
• Protein ID: WP_080344062.1
• Coordinates: 2042256..2042648 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LJU37_RS09705
• Protein ID: WP_047050676.1
• Coordinates: 2041992..2042252 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJU37_RS09680 (LJU37_09680)	2037209..2038330	-	1122	WP_047050671.1	efflux RND transporter periplasmic adaptor subunit	-
LJU37_RS09685 (LJU37_09685)	2038478..2039047	-	570	WP_032103771.1	TetR/AcrR family transcriptional regulator	-
LJU37_RS09690 (LJU37_09690)	2039233..2039652	+	420	WP_047050673.1	GNAT family N-acetyltransferase	-
LJU37_RS09695 (LJU37_09695)	2039649..2040296	-	648	WP_017383663.1	TetR/AcrR family transcriptional regulator	-
LJU37_RS09700 (LJU37_09700)	2040390..2041874	+	1485	WP_227788589.1	MDR family MFS transporter	-
LJU37_RS09705 (LJU37_09705)	2041992..2042252	+	261	WP_047050676.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
LJU37_RS09710 (LJU37_09710)	2042256..2042648	+	393	WP_080344062.1	type II toxin-antitoxin system VapC family toxin	Toxin
LJU37_RS09715 (LJU37_09715)	2042717..2043190	-	474	WP_032674176.1	hypothetical protein	-
LJU37_RS09720 (LJU37_09720)	2043572..2044372	+	801	WP_047050678.1	lipoprotein NlpA	-
LJU37_RS09725 (LJU37_09725)	2044406..2045086	-	681	WP_047050679.1	EAL domain-containing protein	-
LJU37_RS09730 (LJU37_09730)	2045162..2045782	-	621	WP_047050680.1	LuxR C-terminal-related transcriptional regulator	-
LJU37_RS09735 (LJU37_09735)	2046323..2046988	+	666	WP_072190036.1	LuxR C-terminal-related transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-118)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14585.78 Da
• Isoelectric Point: 5.8985

>T221248 WP_080344062.1 NZ_CP085767:2042256-2042648 [Enterobacter hormaechei]
MLHMLDTNIVSHLVRQHPEVVNRYSQITPEKMCISSVTEAELLYGVAKKQNNKLHETIMEFLKTITVCAWDSEAAAIYGE
LRAAMEKKGKVMGDLDQLIAAHAISRGTTIVTNDHAFGMVQDLTVEDWTQ

Nucleotide

• Length: 393 bp

>T221248 NZ_CP117365:c4258006-4257515 [Salmonella enterica subsp. enterica serovar Newport]
ATGATCTCCTCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAGCGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAAGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 10084.38 Da
• Isoelectric Point: 9.6899

>AT221248 WP_047050676.1 NZ_CP085767:2041992-2042252 [Enterobacter hormaechei]
MERTAKLFKKGRNQAVVLPAEFAFETESVYIRRDDEGNVVLTARSEKARHRDNFLRMLKETHVPDTFLSKEERNQSYTTR
NPLEGL

Nucleotide

• Length: 261 bp

>AT221248 NZ_CP117365:c4258296-4258003 [Salmonella enterica subsp. enterica serovar Newport]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCTGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCCTATCAGGAATTTCTGGCTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA