Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 1244580..1245259 Replicon chromosome
Accession NZ_CP085767
Organism Enterobacter hormaechei strain 49589CZ

Toxin (Protein)


Gene name ykfI Uniprot ID A0A411GL63
Locus tag LJU37_RS05920 Protein ID WP_016243829.1
Coordinates 1244580..1244921 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A8B2XJW9
Locus tag LJU37_RS05925 Protein ID WP_016243830.1
Coordinates 1244942..1245259 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU37_RS05900 (LJU37_05900) 1239879..1241682 + 1804 Protein_1146 DNA primase -
LJU37_RS05905 (LJU37_05905) 1241778..1243622 + 1845 WP_006812010.1 RNA polymerase sigma factor RpoD -
LJU37_RS05910 (LJU37_05910) 1243712..1244218 - 507 WP_032649590.1 G/U mismatch-specific DNA glycosylase -
LJU37_RS05920 (LJU37_05920) 1244580..1244921 - 342 WP_016243829.1 TA system toxin CbtA family protein Toxin
LJU37_RS05925 (LJU37_05925) 1244942..1245259 - 318 WP_016243830.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LJU37_RS05930 (LJU37_05930) 1245279..1245500 - 222 WP_007777714.1 DUF987 domain-containing protein -
LJU37_RS05935 (LJU37_05935) 1245509..1245985 - 477 WP_016243831.1 RadC family protein -
LJU37_RS05940 (LJU37_05940) 1246001..1246459 - 459 WP_016243832.1 antirestriction protein -
LJU37_RS05945 (LJU37_05945) 1246561..1246800 - 240 WP_016243833.1 DUF905 domain-containing protein -
LJU37_RS05950 (LJU37_05950) 1246877..1247344 - 468 WP_016239439.1 protein YkfB -
LJU37_RS05955 (LJU37_05955) 1247368..1247811 - 444 WP_016243834.1 hypothetical protein -
LJU37_RS05960 (LJU37_05960) 1247811..1248047 - 237 WP_001115854.1 protein YpjK -
LJU37_RS05965 (LJU37_05965) 1248084..1248785 - 702 WP_047749107.1 WYL domain-containing protein -
LJU37_RS05970 (LJU37_05970) 1249002..1249823 - 822 WP_008324532.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13020.04 Da        Isoelectric Point: 9.9961

>T221246 WP_016243829.1 NZ_CP085767:c1244921-1244580 [Enterobacter hormaechei]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSEERVIQEHIDAGISLADAVNFLVEKYELVRIDRKGF
NWQEQSPYLRAVDILRARQATGLLRQSRKNSVR

Download         Length: 342 bp

>T221246 NZ_CP117365:3642023-3642298 [Salmonella enterica subsp. enterica serovar Newport]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCACCAGTTACTCACATATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACCGTGAAGATCTCCAAGGGATGTT
TGATCCTGATGGCTGAGACGGACGAAGTGAGGGAGCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATGATGTGGTGAACGGGGATTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12041.72 Da        Isoelectric Point: 7.7518

>AT221246 WP_016243830.1 NZ_CP085767:c1245259-1244942 [Enterobacter hormaechei]
MTHITWGLQRNITPRLGARLVQEGNRMHYLADRASITGKFSDTECRKLDETFPHFIRQMESMLTTGEMNPRNAHCVTLFH
NGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp

>AT221246 NZ_CP117365:c3642288-3641866 [Salmonella enterica subsp. enterica serovar Newport]
TTCACCACATCATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGCTCCCTCAC
TTCGTCCGTCTCAGCCATCAGGATCAAACATCCCTTGGAGATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAACA
ACCGGCTACCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A411GL63

Antitoxin

Source ID Structure
AlphaFold DB A0A8B2XJW9

References