Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1017487..1018144 Replicon chromosome
Accession NZ_CP085767
Organism Enterobacter hormaechei strain 49589CZ

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag LJU37_RS04815 Protein ID WP_017382887.1
Coordinates 1017487..1017897 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag LJU37_RS04820 Protein ID WP_003863437.1
Coordinates 1017878..1018144 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU37_RS04795 (LJU37_04795) 1013485..1015218 - 1734 WP_047050807.1 single-stranded-DNA-specific exonuclease RecJ -
LJU37_RS04800 (LJU37_04800) 1015224..1015937 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LJU37_RS04805 (LJU37_04805) 1015966..1016862 - 897 WP_047050805.1 site-specific tyrosine recombinase XerD -
LJU37_RS04810 (LJU37_04810) 1016964..1017485 + 522 WP_015571793.1 flavodoxin FldB -
LJU37_RS04815 (LJU37_04815) 1017487..1017897 - 411 WP_017382887.1 protein YgfX Toxin
LJU37_RS04820 (LJU37_04820) 1017878..1018144 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
LJU37_RS04825 (LJU37_04825) 1018439..1019419 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
LJU37_RS04830 (LJU37_04830) 1019531..1020190 - 660 WP_047050804.1 hemolysin III family protein -
LJU37_RS04835 (LJU37_04835) 1020457..1021188 + 732 WP_047050802.1 MurR/RpiR family transcriptional regulator -
LJU37_RS04840 (LJU37_04840) 1021305..1022738 + 1434 WP_023295383.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T221245 WP_017382887.1 NZ_CP085767:c1017897-1017487 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T221245 NZ_CP117365:3450952-3451170 [Salmonella enterica subsp. enterica serovar Newport]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT221245 WP_003863437.1 NZ_CP085767:c1018144-1017878 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT221245 NZ_CP117365:3450550-3450924 [Salmonella enterica subsp. enterica serovar Newport]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References