Detailed information of TA system TA221244

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA(toxin)
• Location: 283086..284869
• Replicon: chromosome
• Accession: NZ_CP085767
• Organism: Enterobacter hormaechei strain 49589CZ

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LJU37_RS01370
• Protein ID: WP_047053382.1
• Coordinates: 283086..284435 (+)
• Length: 450 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LJU37_RS01375
• Protein ID: WP_047053381.1
• Coordinates: 284432..284869 (+)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJU37_RS01345 (LJU37_01345)	278909..279844	-	936	WP_003859306.1	tRNA dihydrouridine(16) synthase DusC	-
LJU37_RS01350 (LJU37_01350)	280013..280408	+	396	WP_023295055.1	CidA/LrgA family protein	-
LJU37_RS01355 (LJU37_01355)	280405..281100	+	696	WP_015572322.1	CidB/LrgB family autolysis modulator	-
LJU37_RS01360 (LJU37_01360)	281229..282113	+	885	WP_047053384.1	cytidine deaminase	-
LJU37_RS01365 (LJU37_01365)	282241..282951	+	711	WP_003859314.1	outer membrane permeability protein SanA	-
LJU37_RS01370 (LJU37_01370)	283086..284435	+	1350	WP_047053382.1	HipA domain-containing protein	Toxin
LJU37_RS01375 (LJU37_01375)	284432..284869	+	438	WP_047053381.1	helix-turn-helix transcriptional regulator	Antitoxin
LJU37_RS01380 (LJU37_01380)	284908..285918	-	1011	WP_003859318.1	galactose/methyl galactoside ABC transporter permease MglC	-
LJU37_RS01385 (LJU37_01385)	285934..287454	-	1521	WP_003859320.1	galactose/methyl galactoside ABC transporter ATP-binding protein MglA	-
LJU37_RS01390 (LJU37_01390)	287534..288532	-	999	WP_017383382.1	galactose/glucose ABC transporter substrate-binding protein MglB	-
LJU37_RS01395 (LJU37_01395)	288828..289850	-	1023	WP_047053378.1	HTH-type transcriptional regulator GalS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-406)

Antitoxin

• Cro/C1-type helix-turn-helix domain (78-129)

Sequences

Toxin

Protein

• Length: 450 a.a.
• Molecular weight: 51132.76 Da
• Isoelectric Point: 4.6556

>T221244 WP_047053382.1 NZ_CP085767:283086-284435 [Enterobacter hormaechei]
METLTVQAYLNETWTDIALIKYPGSEKNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLTCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFHYIPDKLSRWGLL

Nucleotide

• Length: 1350 bp

>T221244 NZ_CP117365:2009960-2010063 [Salmonella enterica subsp. enterica serovar Newport]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 16161.57 Da
• Isoelectric Point: 10.5154

>AT221244 WP_047053381.1 NZ_CP085767:284432-284869 [Enterobacter hormaechei]
MKTSNEAESELLQTLAQVRSVNKKRHHDEAEDPDKPSVVKRQRVSQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADIINKIFKPFGLQTGLVPVSKSLIASLFS

Nucleotide

• Length: 438 bp

>AT221244 NZ_CP117365:c2010065-2009920 [Salmonella enterica subsp. enterica serovar Newport]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG