Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/ElaA-DUF1778 |
| Location | 123533..124272 | Replicon | plasmid p60214CZ_IncFII |
| Accession | NZ_CP085746 | ||
| Organism | Enterobacter hormaechei strain 60214CZ | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | A0A5E1AVR5 |
| Locus tag | LJU47_RS23175 | Protein ID | WP_013087172.1 |
| Coordinates | 123533..124018 (-) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | A0A5E1AWX8 |
| Locus tag | LJU47_RS23180 | Protein ID | WP_012540086.1 |
| Coordinates | 124006..124272 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJU47_RS23155 (119522) | 119522..119791 | + | 270 | WP_004196355.1 | nickel-sensing transcriptional repressor NcrB | - |
| LJU47_RS23160 (119804) | 119804..120934 | + | 1131 | WP_004196366.1 | Ni(II)/Co(II) efflux transporter permease subunit NcrC | - |
| LJU47_RS23165 (121096) | 121096..121518 | + | 423 | WP_032072095.1 | nickel resistance OB fold protein NcrY | - |
| LJU47_RS23170 (121774) | 121774..123114 | - | 1341 | WP_000589001.1 | ISNCY family transposase | - |
| LJU47_RS23175 (123533) | 123533..124018 | - | 486 | WP_013087172.1 | GNAT family N-acetyltransferase | Toxin |
| LJU47_RS23180 (124006) | 124006..124272 | - | 267 | WP_012540086.1 | DUF1778 domain-containing protein | Antitoxin |
| LJU47_RS23185 (124573) | 124573..124896 | + | 324 | WP_013087171.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| LJU47_RS23190 (124898) | 124898..125611 | + | 714 | WP_013087170.1 | arsenical resistance protein ArsH | - |
| LJU47_RS23195 (125620) | 125620..126165 | + | 546 | WP_013087169.1 | sigma-70 family RNA polymerase sigma factor | - |
| LJU47_RS23200 (126241) | 126241..126603 | + | 363 | WP_013087168.1 | arsenic metallochaperone ArsD family protein | - |
| LJU47_RS23205 (126624) | 126624..128324 | + | 1701 | Protein_148 | arsenical pump-driving ATPase | - |
| LJU47_RS23210 (128321) | 128321..129139 | - | 819 | Protein_149 | TRC40/GET3/ArsA family transport-energizing ATPase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | blaOXA-1 / aac(6')-Ib-cr / dfrA14 / sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / blaCTX-M-15 / aac(3)-IIa | - | 1..159360 | 159360 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17810.62 Da Isoelectric Point: 9.8560
>T221181 WP_013087172.1 NZ_CP085746:c124018-123533 [Enterobacter hormaechei]
VGRVTVPEPLSSFHQVAEFVCGETVLDDWLKQKGLKNQALGSARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQQRTLFLKLP
Q
VGRVTVPEPLSSFHQVAEFVCGETVLDDWLKQKGLKNQALGSARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQQRTLFLKLP
Q
Download Length: 486 bp
>T221181 NZ_CP117355:c14266-13916 [Salmonella enterica subsp. enterica serovar Dublin]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10076.47 Da Isoelectric Point: 4.3721
>AT221181 WP_012540086.1 NZ_CP085746:c124272-124006 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIDKLL
ARKPQWDV
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIDKLL
ARKPQWDV
Download Length: 267 bp
>AT221181 NZ_CP117355:c13911-13609 [Salmonella enterica subsp. enterica serovar Dublin]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5E1AVR5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5E1AWX8 |