Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 109179..109705 Replicon plasmid p60214CZ_IncFII
Accession NZ_CP085746
Organism Enterobacter hormaechei strain 60214CZ

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag LJU47_RS23085 Protein ID WP_000323025.1
Coordinates 109179..109466 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag LJU47_RS23090 Protein ID WP_004196370.1
Coordinates 109466..109705 (-) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU47_RS23055 (105848) 105848..106048 - 201 WP_013087182.1 hypothetical protein -
LJU47_RS23060 (106136) 106136..106597 - 462 WP_013087181.1 hypothetical protein -
LJU47_RS23065 (106658) 106658..106972 - 315 WP_044157807.1 hypothetical protein -
LJU47_RS23070 (107852) 107852..107962 - 111 WP_230678187.1 DUF5431 family protein -
LJU47_RS23080 (108078) 108078..109112 + 1035 Protein_123 IS481 family transposase -
LJU47_RS23085 (109179) 109179..109466 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
LJU47_RS23090 (109466) 109466..109705 - 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
LJU47_RS23095 (109730) 109730..109828 + 99 Protein_126 protein YdfV -
LJU47_RS23100 (110025) 110025..111145 + 1121 WP_087451024.1 IS3-like element ISSen4 family transposase -
LJU47_RS23105 (111181) 111181..111546 + 366 WP_009651956.1 hypothetical protein -
LJU47_RS23110 (111590) 111590..112327 + 738 WP_008460272.1 HupE/UreJ family protein -
LJU47_RS23115 (112341) 112341..113030 + 690 WP_013087175.1 hypothetical protein -
LJU47_RS23120 (113061) 113061..114437 - 1377 WP_004196363.1 chromate efflux transporter -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-1 / aac(6')-Ib-cr / dfrA14 / sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / blaCTX-M-15 / aac(3)-IIa - 1..159360 159360
- inside IScluster/Tn - - 108078..111145 3067


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T221180 WP_000323025.1 NZ_CP085746:c109466-109179 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T221180 NZ_CP085746:c109466-109179 [Enterobacter hormaechei]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT221180 WP_004196370.1 NZ_CP085746:c109705-109466 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp

>AT221180 NZ_CP085746:c109705-109466 [Enterobacter hormaechei]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTTGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References