Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 53124..53863 Replicon plasmid p60214CZ_IncFII
Accession NZ_CP085746
Organism Enterobacter hormaechei strain 60214CZ

Toxin (Protein)


Gene name tacT Uniprot ID A0A9E6WPH7
Locus tag LJU47_RS22755 Protein ID WP_013087269.1
Coordinates 53378..53863 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A9E6WPN8
Locus tag LJU47_RS22750 Protein ID WP_007869691.1
Coordinates 53124..53390 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU47_RS22725 (48191) 48191..48961 + 771 WP_013087103.1 TraX family protein -
LJU47_RS22730 (48976) 48976..49314 + 339 WP_013087102.1 hypothetical protein -
LJU47_RS22735 (49397) 49397..49726 + 330 WP_013087101.1 hypothetical protein -
LJU47_RS22740 (49701) 49701..50507 - 807 WP_013087100.1 DUF4225 domain-containing protein -
LJU47_RS22745 (51458) 51458..52471 - 1014 WP_013087098.1 plasmid replication initiator RepA -
LJU47_RS22750 (53124) 53124..53390 + 267 WP_007869691.1 DUF1778 domain-containing protein Antitoxin
LJU47_RS22755 (53378) 53378..53863 + 486 WP_013087269.1 GNAT family N-acetyltransferase Toxin
LJU47_RS22760 (54230) 54230..55048 - 819 WP_013087268.1 abortive infection family protein -
LJU47_RS22770 (55797) 55797..56627 - 831 WP_100135202.1 hypothetical protein -
LJU47_RS22775 (56761) 56761..57399 - 639 WP_008786709.1 DUF2913 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-1 / aac(6')-Ib-cr / dfrA14 / sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / blaCTX-M-15 / aac(3)-IIa - 1..159360 159360


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-146)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17736.45 Da        Isoelectric Point: 9.5181

>T221179 WP_013087269.1 NZ_CP085746:53378-53863 [Enterobacter hormaechei]
VGRVTAPEPLSSSHQLAEFVSGEAVLDDWLKQRGLKNQALGAARTFVVCKRDTKQVVGFYSLATGSVNHVEAMGSLRRNM
PDPIPVIILARLAVDVSYRGQGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYLHHGFKASQTQERTLFLKLP
Q

Download         Length: 486 bp

>T221179 NZ_CP117354:c4652708-4652397 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10080.46 Da        Isoelectric Point: 4.3837

>AT221179 WP_007869691.1 NZ_CP085746:53124-53390 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVSDEAAIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT221179 NZ_CP117354:c4652396-4652106 [Salmonella enterica subsp. enterica serovar Dublin]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References