Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 4248308..4250091 Replicon chromosome
Accession NZ_CP085743
Organism Enterobacter hormaechei strain 60214CZ

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LJU47_RS20460 Protein ID WP_227793122.1
Coordinates 4248742..4250091 (-) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A837FFV9
Locus tag LJU47_RS20455 Protein ID WP_003859317.1
Coordinates 4248308..4248745 (-) Length 146 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU47_RS20435 (LJU47_20435) 4243327..4244349 + 1023 WP_003859324.1 HTH-type transcriptional regulator GalS -
LJU47_RS20440 (LJU47_20440) 4244645..4245643 + 999 WP_017383382.1 galactose/glucose ABC transporter substrate-binding protein MglB -
LJU47_RS20445 (LJU47_20445) 4245723..4247243 + 1521 WP_003859320.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
LJU47_RS20450 (LJU47_20450) 4247259..4248269 + 1011 WP_003859318.1 galactose/methyl galactoside ABC transporter permease MglC -
LJU47_RS20455 (LJU47_20455) 4248308..4248745 - 438 WP_003859317.1 helix-turn-helix transcriptional regulator Antitoxin
LJU47_RS20460 (LJU47_20460) 4248742..4250091 - 1350 WP_227793122.1 HipA domain-containing protein Toxin
LJU47_RS20465 (LJU47_20465) 4250226..4250936 - 711 WP_003859314.1 outer membrane permeability protein SanA -
LJU47_RS20470 (LJU47_20470) 4251064..4251948 - 885 WP_003859312.1 cytidine deaminase -
LJU47_RS20475 (LJU47_20475) 4252077..4252772 - 696 WP_003859310.1 CidB/LrgB family autolysis modulator -
LJU47_RS20480 (LJU47_20480) 4252769..4253164 - 396 WP_060580135.1 CidA/LrgA family protein -
LJU47_RS20485 (LJU47_20485) 4253333..4254268 + 936 WP_060580134.1 tRNA dihydrouridine(16) synthase DusC -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(166-404)

Antitoxin

(75-128)


Sequences


Toxin        


Download         Length: 450 a.a.        Molecular weight: 51092.83 Da        Isoelectric Point: 4.6498

>T221176 WP_227793122.1 NZ_CP085743:c4250091-4248742 [Enterobacter hormaechei]
METLTVQAYLNETWTDIALIKYPGSEKNDWNITQLDYLTEYAINFLDYDDFHAVPVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYQFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGGYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL

Download         Length: 1350 bp

>T221176 NZ_CP117354:c4195300-4194992 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16185.64 Da        Isoelectric Point: 10.5154

>AT221176 WP_003859317.1 NZ_CP085743:c4248745-4248308 [Enterobacter hormaechei]
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEEPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS

Download         Length: 438 bp

>AT221176 NZ_CP117354:c4195542-4195303 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A837FFV9

References