Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3591366..3592023 Replicon chromosome
Accession NZ_CP085743
Organism Enterobacter hormaechei strain 60214CZ

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag LJU47_RS17435 Protein ID WP_022649305.1
Coordinates 3591613..3592023 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag LJU47_RS17430 Protein ID WP_003863437.1
Coordinates 3591366..3591632 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU47_RS17410 (LJU47_17410) 3586798..3588231 - 1434 WP_003863430.1 6-phospho-beta-glucosidase BglA -
LJU47_RS17415 (LJU47_17415) 3588348..3589079 - 732 WP_023314798.1 MurR/RpiR family transcriptional regulator -
LJU47_RS17420 (LJU47_17420) 3589346..3590005 + 660 WP_023314797.1 hemolysin III family protein -
LJU47_RS17425 (LJU47_17425) 3590091..3591071 - 981 WP_023314796.1 tRNA-modifying protein YgfZ -
LJU47_RS17430 (LJU47_17430) 3591366..3591632 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
LJU47_RS17435 (LJU47_17435) 3591613..3592023 + 411 WP_022649305.1 protein YgfX Toxin
LJU47_RS17440 (LJU47_17440) 3592025..3592546 - 522 WP_003863440.1 flavodoxin FldB -
LJU47_RS17445 (LJU47_17445) 3592648..3593544 + 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
LJU47_RS17450 (LJU47_17450) 3593573..3594286 + 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LJU47_RS17455 (LJU47_17455) 3594292..3596025 + 1734 WP_058658593.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T221174 WP_022649305.1 NZ_CP085743:3591613-3592023 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T221174 NZ_CP117354:3736199-3736456 [Salmonella enterica subsp. enterica serovar Dublin]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCAAAACCCACATGACCACCTATTACTCACAAATCCCCAGCCT
GCATCTTAAGGGCGACTGGCTGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAGCAGCTTTATCAGGCTAAACAGGTGGTTAAGGGAATT
AAGGACGTGCTGGTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT221174 WP_003863437.1 NZ_CP085743:3591366-3591632 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT221174 NZ_CP117354:c3736374-3736042 [Salmonella enterica subsp. enterica serovar Dublin]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References