Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3663092..3663766 Replicon chromosome
Accession NZ_CP085532
Organism Mycobacterium tuberculosis variant bovis BCG strain Moreau PL

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag LJF87_RS17290 Protein ID WP_003417282.1
Coordinates 3663092..3663520 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag LJF87_RS17295 Protein ID WP_003417286.1
Coordinates 3663524..3663766 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF87_RS17265 (LJF87_17255) 3658815..3659216 - 402 WP_003417264.1 cytidine deaminase -
LJF87_RS17270 (LJF87_17260) 3659453..3659791 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
LJF87_RS17275 (LJF87_17265) 3659788..3660222 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
LJF87_RS17280 (LJF87_17270) 3660450..3662222 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
LJF87_RS17285 (LJF87_17275) 3662222..3663013 + 792 WP_010950870.1 succinate dehydrogenase iron-sulfur subunit -
LJF87_RS17290 (LJF87_17280) 3663092..3663520 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
LJF87_RS17295 (LJF87_17285) 3663524..3663766 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
LJF87_RS17300 (LJF87_17290) 3663888..3664502 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
LJF87_RS17305 (LJF87_17295) 3664499..3665164 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
LJF87_RS17310 (LJF87_17300) 3665165..3665698 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
LJF87_RS17315 (LJF87_17305) 3665695..3666069 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
LJF87_RS17320 (LJF87_17310) 3666166..3667302 - 1137 WP_003417297.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T220900 WP_003417282.1 NZ_CP085532:c3663520-3663092 [Mycobacterium tuberculosis variant bovis BCG]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T220900 NZ_CP117299:c4650430-4650155 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGGGACAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT220900 WP_003417286.1 NZ_CP085532:c3663766-3663524 [Mycobacterium tuberculosis variant bovis BCG]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT220900 NZ_CP117299:c4650693-4650433 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCATTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References