Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VapB |
| Location | 3007251..3007938 | Replicon | chromosome |
| Accession | NZ_CP085532 | ||
| Organism | Mycobacterium tuberculosis variant bovis BCG strain Moreau PL | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | G0TF65 |
| Locus tag | LJF87_RS14235 | Protein ID | WP_003414064.1 |
| Coordinates | 3007543..3007938 (-) | Length | 132 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | G0TF64 |
| Locus tag | LJF87_RS14230 | Protein ID | WP_003414061.1 |
| Coordinates | 3007251..3007517 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJF87_RS14205 (LJF87_14195) | 3002890..3003792 | - | 903 | WP_003900564.1 | 4-hydroxy-tetrahydrodipicolinate synthase | - |
| LJF87_RS14210 (LJF87_14200) | 3003861..3004613 | - | 753 | WP_003899465.1 | FAD-dependent thymidylate synthase | - |
| LJF87_RS14215 (LJF87_14210) | 3004857..3005132 | - | 276 | WP_003414055.1 | type I restriction endonuclease subunit S | - |
| LJF87_RS14220 (LJF87_14215) | 3005129..3006751 | - | 1623 | WP_003414057.1 | class I SAM-dependent DNA methyltransferase | - |
| LJF87_RS14225 (LJF87_14220) | 3006838..3007254 | - | 417 | WP_003414059.1 | type II toxin-antitoxin system toxin ribonuclease C21 | - |
| LJF87_RS14230 (LJF87_14225) | 3007251..3007517 | - | 267 | WP_003414061.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| LJF87_RS14235 (LJF87_14230) | 3007543..3007938 | - | 396 | WP_003414064.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LJF87_RS14240 (LJF87_14235) | 3007935..3008204 | - | 270 | WP_003414066.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| LJF87_RS14245 (LJF87_14240) | 3008214..3009308 | - | 1095 | WP_003414068.1 | restriction endonuclease subunit S | - |
| LJF87_RS14250 (LJF87_14245) | 3009305..3009724 | - | 420 | Protein_2811 | winged helix-turn-helix domain-containing protein | - |
| LJF87_RS14255 (LJF87_14250) | 3009723..3009797 | + | 75 | Protein_2812 | hypothetical protein | - |
| LJF87_RS14260 (LJF87_14255) | 3009798..3010277 | - | 480 | WP_003414073.1 | dihydrofolate reductase | - |
| LJF87_RS14265 (LJF87_14260) | 3010348..3011148 | - | 801 | WP_003911953.1 | thymidylate synthase | - |
| LJF87_RS14270 (LJF87_14265) | 3011304..3012041 | + | 738 | WP_011799288.1 | dienelactone hydrolase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 132 a.a. Molecular weight: 14340.04 Da Isoelectric Point: 4.7145
>T220893 WP_003414064.1 NZ_CP085532:c3007938-3007543 [Mycobacterium tuberculosis variant bovis BCG]
VIVDTSAIVAIVSGESGAQVLKEALERSPNSRMSAPNYVELCAIMQRRDRPEISRLVDRLLDDYGIQVEAVDADQARVAA
QAYRDYGRGSGHPARLNLGDTYSYALAQVTGEPLLFRGDDFTHTDIRPACT
VIVDTSAIVAIVSGESGAQVLKEALERSPNSRMSAPNYVELCAIMQRRDRPEISRLVDRLLDDYGIQVEAVDADQARVAA
QAYRDYGRGSGHPARLNLGDTYSYALAQVTGEPLLFRGDDFTHTDIRPACT
Download Length: 396 bp
>T220893 NZ_CP117299:c1442756-1442511 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGAATGCCTCCGGCGCCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCGG
CGACTGCCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACGGTGAAGATTTCGGACGGGTGTATTGTGCTAATGG
CGGACGGTAACGAGGTGCAGAAGCTGTGCGAACAGCTTTACAAGGCTGAACAGGTAGTTAAGGGGATGTGGGACGTGATT
GTTTAG
ATGAATGCCTCCGGCGCCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCGG
CGACTGCCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACGGTGAAGATTTCGGACGGGTGTATTGTGCTAATGG
CGGACGGTAACGAGGTGCAGAAGCTGTGCGAACAGCTTTACAAGGCTGAACAGGTAGTTAAGGGGATGTGGGACGTGATT
GTTTAG
Antitoxin
Download Length: 89 a.a. Molecular weight: 9493.77 Da Isoelectric Point: 7.2783
>AT220893 WP_003414061.1 NZ_CP085532:c3007517-3007251 [Mycobacterium tuberculosis variant bovis BCG]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
Download Length: 267 bp
>AT220893 NZ_CP117299:1442606-1442913 [Salmonella enterica subsp. enterica serovar Mbandaka]
CAATACACCCGTCCGAAATCTTCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGG
ATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGGCGCCGGAGGCATTCATATTTGCTGA
CTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCATGG
CACCGCGCCTCCCTCTCCCCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT
CAATACACCCGTCCGAAATCTTCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGG
ATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGGCGCCGGAGGCATTCATATTTGCTGA
CTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCATGG
CACCGCGCCTCCCTCTCCCCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|