Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2801282..2801922 Replicon chromosome
Accession NZ_CP085532
Organism Mycobacterium tuberculosis variant bovis BCG strain Moreau PL

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ08
Locus tag LJF87_RS13100 Protein ID WP_003412970.1
Coordinates 2801282..2801701 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ09
Locus tag LJF87_RS13105 Protein ID WP_003412975.1
Coordinates 2801698..2801922 (-) Length 75 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF87_RS13070 (LJF87_13060) 2796867..2797589 - 723 WP_003412957.1 DUF1906 domain-containing protein -
LJF87_RS13075 (LJF87_13065) 2798106..2798333 + 228 WP_003412960.1 type II toxin-antitoxin system VapB family antitoxin -
LJF87_RS13080 (LJF87_13070) 2798330..2798731 + 402 WP_003412963.1 PIN domain-containing protein -
LJF87_RS13085 (LJF87_13075) 2798766..2799686 - 921 WP_011799273.1 restriction endonuclease -
LJF87_RS13090 (LJF87_13080) 2800027..2800272 - 246 WP_071854223.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
LJF87_RS13095 (LJF87_13085) 2800331..2801281 + 951 WP_003911916.1 ERCC4 domain-containing protein -
LJF87_RS13100 (LJF87_13090) 2801282..2801701 - 420 WP_003412970.1 type II toxin-antitoxin system VapC family toxin Toxin
LJF87_RS13105 (LJF87_13095) 2801698..2801922 - 225 WP_003412975.1 antitoxin VapB39 Antitoxin
LJF87_RS13110 (LJF87_13100) 2801953..2804796 - 2844 WP_003899363.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
LJF87_RS13115 (LJF87_13105) 2804868..2805269 - 402 WP_003412981.1 hypothetical protein -
LJF87_RS13120 (LJF87_13110) 2805269..2805739 - 471 WP_003412985.1 transcription antitermination factor NusB -
LJF87_RS13125 (LJF87_13115) 2805742..2806305 - 564 WP_003412989.1 elongation factor P -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-128)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 140 a.a.        Molecular weight: 14732.70 Da        Isoelectric Point: 6.7519

>T220887 WP_003412970.1 NZ_CP085532:c2801701-2801282 [Mycobacterium tuberculosis variant bovis BCG]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Download         Length: 420 bp

>T220887 NZ_CP117299:693128-693619 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGATCTCCTCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGCGGGTGGGGTTTGAACCATCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 7993.94 Da        Isoelectric Point: 4.0057

>AT220887 WP_003412975.1 NZ_CP085532:c2801922-2801698 [Mycobacterium tuberculosis variant bovis BCG]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Download         Length: 225 bp

>AT220887 NZ_CP117299:692838-693131 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGTCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCACAGGCTTATCAGGAATTTCTCGCTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCACCGTGGGAGCAGGAAAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TQ08


Antitoxin

Source ID Structure
AlphaFold DB G0TQ09

References