Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2188337..2188881 | Replicon | chromosome |
| Accession | NZ_CP085532 | ||
| Organism | Mycobacterium tuberculosis variant bovis BCG strain Moreau PL | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | LJF87_RS10190 | Protein ID | WP_003409896.1 |
| Coordinates | 2188337..2188633 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | LJF87_RS10195 | Protein ID | WP_003409899.1 |
| Coordinates | 2188630..2188881 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJF87_RS10135 (LJF87_10130) | 2183370..2183720 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| LJF87_RS10140 (LJF87_10135) | 2183731..2184633 | - | 903 | WP_003409874.1 | hypothetical protein | - |
| LJF87_RS10145 (LJF87_10140) | 2184654..2184845 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| LJF87_RS10150 (LJF87_10145) | 2184846..2185142 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| LJF87_RS10155 (LJF87_10150) | 2185382..2185597 | + | 216 | WP_003409878.1 | antitoxin | - |
| LJF87_RS10160 (LJF87_10155) | 2185594..2185905 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| LJF87_RS10165 (LJF87_10160) | 2185879..2186400 | - | 522 | WP_010950637.1 | hypothetical protein | - |
| LJF87_RS10170 (LJF87_10165) | 2186375..2186752 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| LJF87_RS10175 (LJF87_10170) | 2186794..2187243 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| LJF87_RS10180 (LJF87_10175) | 2187240..2187785 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| LJF87_RS10185 (LJF87_10180) | 2187674..2188288 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| LJF87_RS10190 (LJF87_10185) | 2188337..2188633 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LJF87_RS10195 (LJF87_10190) | 2188630..2188881 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| LJF87_RS10200 (LJF87_10195) | 2188868..2189362 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| LJF87_RS10205 (LJF87_10200) | 2189522..2189929 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| LJF87_RS10210 (LJF87_10205) | 2189933..2190205 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| LJF87_RS10215 (LJF87_10210) | 2190238..2191458 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| LJF87_RS10220 (LJF87_10215) | 2192357..2192662 | + | 306 | Protein_2019 | ABC transporter permease | - |
| LJF87_RS10225 (LJF87_10220) | 2192658..2192738 | + | 81 | Protein_2020 | hypothetical protein | - |
| LJF87_RS10230 (LJF87_10225) | 2192846..2193694 | + | 849 | WP_003409942.1 | class I SAM-dependent methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T220878 WP_003409896.1 NZ_CP085532:c2188633-2188337 [Mycobacterium tuberculosis variant bovis BCG]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T220878 NZ_CP117298:3127991-3128254 [Mycobacterium tuberculosis variant bovis]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT220878 WP_003409899.1 NZ_CP085532:c2188881-2188630 [Mycobacterium tuberculosis variant bovis BCG]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT220878 NZ_CP117298:3127706-3127987 [Mycobacterium tuberculosis variant bovis]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |