Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1946271..1946731 Replicon chromosome
Accession NZ_CP085532
Organism Mycobacterium tuberculosis variant bovis BCG strain Moreau PL

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FB26
Locus tag LJF87_RS09085 Protein ID WP_003408531.1
Coordinates 1946483..1946731 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag LJF87_RS09080 Protein ID WP_003408528.1
Coordinates 1946271..1946483 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF87_RS09065 (LJF87_09045) 1942749..1943936 - 1188 WP_003898992.1 nitrate transporter NarK -
LJF87_RS09070 (LJF87_09050) 1944223..1944507 + 285 WP_003408522.1 DUF1876 domain-containing protein -
LJF87_RS09075 (LJF87_09055) 1944521..1946203 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
LJF87_RS09080 (LJF87_09060) 1946271..1946483 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LJF87_RS09085 (LJF87_09065) 1946483..1946731 + 249 WP_003408531.1 hypothetical protein Toxin
LJF87_RS09090 (LJF87_09070) 1946739..1947477 + 739 Protein_1793 hypothetical protein -
LJF87_RS09095 (LJF87_09075) 1947571..1949271 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
LJF87_RS09100 (LJF87_09080) 1949556..1949957 - 402 WP_010950586.1 hypothetical protein -
LJF87_RS09105 (LJF87_09085) 1949947..1950558 - 612 Protein_1796 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8857.07 Da        Isoelectric Point: 3.9794

>T220875 WP_003408531.1 NZ_CP085532:1946483-1946731 [Mycobacterium tuberculosis variant bovis BCG]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYTGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T220875 NZ_CP117298:c3060249-3059893 [Mycobacterium tuberculosis variant bovis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT220875 WP_003408528.1 NZ_CP085532:1946271-1946483 [Mycobacterium tuberculosis variant bovis BCG]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT220875 NZ_CP117298:c3060463-3060233 [Mycobacterium tuberculosis variant bovis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB26

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References