Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 704611..705254 Replicon chromosome
Accession NZ_CP085532
Organism Mycobacterium tuberculosis variant bovis BCG strain Moreau PL

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag LJF87_RS03210 Protein ID WP_003403187.1
Coordinates 704853..705254 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag LJF87_RS03205 Protein ID WP_003403184.1
Coordinates 704611..704856 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF87_RS03170 (LJF87_03140) 699891..700421 - 531 WP_003917320.1 two component system sensor kinase HK2 -
LJF87_RS03175 (LJF87_03145) 700405..701100 - 696 WP_197044064.1 two-component system response regulator TcrA -
LJF87_RS03180 (LJF87_03150) 701223..701534 + 312 WP_003403164.1 hypothetical protein -
LJF87_RS03185 (LJF87_03155) 701606..702556 + 951 WP_003907436.1 DUF1259 domain-containing protein -
LJF87_RS03190 (LJF87_03160) 702797..703381 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
LJF87_RS03195 (LJF87_03165) 703383..704093 + 711 Protein_633 IS607 family element RNA-guided endonuclease TnpB -
LJF87_RS03200 (LJF87_03170) 704096..704566 + 471 WP_003898523.1 hypothetical protein -
LJF87_RS03205 (LJF87_03175) 704611..704856 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LJF87_RS03210 (LJF87_03180) 704853..705254 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
LJF87_RS03215 (LJF87_03185) 705245..705424 + 180 Protein_637 hypothetical protein -
LJF87_RS03220 (LJF87_03195) 705842..706039 - 198 WP_003403191.1 hypothetical protein -
LJF87_RS03225 (LJF87_03200) 706119..707276 - 1158 WP_003403193.1 hypothetical protein -
LJF87_RS03230 (LJF87_03205) 707328..707549 - 222 WP_003898525.1 DUF4926 domain-containing protein -
LJF87_RS03235 (LJF87_03210) 707691..708296 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T220854 WP_003403187.1 NZ_CP085532:704853-705254 [Mycobacterium tuberculosis variant bovis BCG]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T220854 NZ_CP117298:1753446-1753850 [Mycobacterium tuberculosis variant bovis]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT220854 WP_003403184.1 NZ_CP085532:704611-704856 [Mycobacterium tuberculosis variant bovis BCG]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT220854 NZ_CP117298:1753237-1753440 [Mycobacterium tuberculosis variant bovis]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References