Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 867969..868516 Replicon chromosome
Accession NC_009456
Organism Vibrio cholerae O395

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3AD26
Locus tag VC0395_RS04065 Protein ID WP_000807826.1
Coordinates 867969..868271 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag VC0395_RS04070 Protein ID WP_000861987.1
Coordinates 868259..868516 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VC0395_RS04035 863244..863639 - 396 WP_000870868.1 DUF3465 domain-containing protein -
VC0395_RS19925 863925..864248 - 324 WP_001999495.1 DUF3709 domain-containing protein -
VC0395_RS04040 864432..864818 - 387 WP_001015083.1 MmcQ/YjbR family DNA-binding protein -
VC0395_RS04045 864958..865884 - 927 WP_000377815.1 hypothetical protein -
VC0395_RS04050 866033..866395 - 363 WP_002034853.1 hypothetical protein -
VC0395_RS04055 866735..866956 - 222 WP_032074688.1 DUF3709 domain-containing protein -
VC0395_RS20735 866977..867129 - 153 Protein_788 DUF3709 domain-containing protein -
VC0395_RS19930 867119..867235 - 117 WP_114732087.1 DUF3265 domain-containing protein -
VC0395_RS04060 867226..867807 - 582 WP_001025027.1 hypothetical protein -
VC0395_RS04065 867969..868271 - 303 WP_000807826.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VC0395_RS04070 868259..868516 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VC0395_RS04080 869122..869358 - 237 WP_001065132.1 hypothetical protein -
VC0395_RS04085 869602..870027 - 426 WP_000403003.1 GNAT family N-acetyltransferase -
VC0395_RS04090 870122..870532 - 411 WP_000452031.1 hypothetical protein -
VC0395_RS04095 870647..871207 - 561 Protein_796 hypothetical protein -
VC0395_RS04100 871207..871899 - 693 WP_000780703.1 hypothetical protein -
VC0395_RS04105 872107..872289 - 183 WP_001889223.1 DUF645 family protein -
VC0395_RS04115 872584..873033 - 450 WP_000480555.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 833458..916350 82892


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11725.65 Da        Isoelectric Point: 5.1972

>T22079 WP_000807826.1 NC_009456:c868271-867969 [Vibrio cholerae O395]
MAEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPLELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T22079 NC_009456:c868271-867969 [Vibrio cholerae O395]
ATGGCTGAAATAATTTGGACGGAGCCGGCTCTATCCGACCTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTCGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTT
TAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAATCCGTGTCGTGTTTTCTATAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT22079 WP_000861987.1 NC_009456:c868516-868259 [Vibrio cholerae O395]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT22079 NC_009456:c868516-868259 [Vibrio cholerae O395]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGTGGAGAGCGAGCTCTAGCGGATGGCAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3AD26

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References