Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazF-pemI/MazF(toxin) |
| Location | 2185757..2186393 | Replicon | chromosome |
| Accession | NZ_CP085485 | ||
| Organism | Priestia aryabhattai strain KNUC0118 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | D5DWT4 |
| Locus tag | IUJ58_RS10860 | Protein ID | WP_013055004.1 |
| Coordinates | 2185757..2186107 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | pemI | Uniprot ID | D5DWT3 |
| Locus tag | IUJ58_RS10865 | Protein ID | WP_013055003.1 |
| Coordinates | 2186112..2186393 (-) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IUJ58_RS10825 (IUJ58_10795) | 2181343..2182137 | - | 795 | WP_013055011.1 | RNA polymerase sigma factor SigB | - |
| IUJ58_RS10830 (IUJ58_10800) | 2182103..2182588 | - | 486 | WP_025753516.1 | anti-sigma B factor RsbW | - |
| IUJ58_RS10835 (IUJ58_10805) | 2182585..2182917 | - | 333 | WP_013055009.1 | anti-sigma factor antagonist | - |
| IUJ58_RS10840 (IUJ58_10810) | 2182977..2183987 | - | 1011 | WP_045295109.1 | PP2C family protein-serine/threonine phosphatase | - |
| IUJ58_RS10845 (IUJ58_10815) | 2184001..2184402 | - | 402 | WP_013055007.1 | anti-sigma regulatory factor | - |
| IUJ58_RS10850 (IUJ58_10820) | 2184406..2184762 | - | 357 | WP_013055006.1 | STAS domain-containing protein | - |
| IUJ58_RS10855 (IUJ58_10825) | 2184765..2185601 | - | 837 | WP_013055005.1 | RsbT co-antagonist protein RsbRA | - |
| IUJ58_RS10860 (IUJ58_10830) | 2185757..2186107 | - | 351 | WP_013055004.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
| IUJ58_RS10865 (IUJ58_10835) | 2186112..2186393 | - | 282 | WP_013055003.1 | hypothetical protein | Antitoxin |
| IUJ58_RS10870 (IUJ58_10840) | 2186594..2187784 | - | 1191 | WP_216143188.1 | alanine racemase | - |
| IUJ58_RS10875 (IUJ58_10845) | 2187898..2188956 | - | 1059 | WP_013055001.1 | outer membrane lipoprotein carrier protein LolA | - |
| IUJ58_RS10880 (IUJ58_10850) | 2189015..2189380 | - | 366 | WP_028411881.1 | holo-ACP synthase | - |
| IUJ58_RS10885 (IUJ58_10855) | 2189445..2190047 | + | 603 | WP_216143189.1 | rhomboid family intramembrane serine protease | - |
| IUJ58_RS10890 (IUJ58_10860) | 2190056..2191027 | - | 972 | WP_274448507.1 | UV DNA damage repair endonuclease UvsE | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12991.96 Da Isoelectric Point: 4.8781
>T220787 WP_013055004.1 NZ_CP085485:c2186107-2185757 [Priestia aryabhattai]
MVVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDRVDEALQISVGLIDF
MVVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDRVDEALQISVGLIDF
Download Length: 351 bp
>T220787 NZ_CP117291:c4126647-4126159 [Salmonella enterica subsp. enterica serovar Typhi]
ATGATCTCCGCCCCTGAACCGCTTCATGCCGGGCATATTCTTACCCCCTTCTGCTGCGGTGTGGATTCAATGGATAACTG
GCTAAAACAGCGGGCGATGAAAAATCAGGTAACTGGCGCATCCCGTACCTTTGTGTGTTGCGGCAGCGATTCTGACGTAC
TGGCGTATTATTCGCTGGCGTCCAGCGCGGTAACGACAAACACCGCCCCCGGTCGCTTTCGTCGCAATATGCCCGATCCG
ATCCCGGTTGTGGTGCTGGGCCGTCTGGCGGTGGATCGGTCGCTACATGGGCAGGGCGTAGGTCGGGCGCTGGTGAGGGA
TGCCGGGCTGCGGGTGATTCAGGTGGCGGAAACTATCGGTATTCGCGGGATGCTGGTCCATGCCCTGTCGGATGAAGCGC
GGGAGTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTT
CATGCCTGA
ATGATCTCCGCCCCTGAACCGCTTCATGCCGGGCATATTCTTACCCCCTTCTGCTGCGGTGTGGATTCAATGGATAACTG
GCTAAAACAGCGGGCGATGAAAAATCAGGTAACTGGCGCATCCCGTACCTTTGTGTGTTGCGGCAGCGATTCTGACGTAC
TGGCGTATTATTCGCTGGCGTCCAGCGCGGTAACGACAAACACCGCCCCCGGTCGCTTTCGTCGCAATATGCCCGATCCG
ATCCCGGTTGTGGTGCTGGGCCGTCTGGCGGTGGATCGGTCGCTACATGGGCAGGGCGTAGGTCGGGCGCTGGTGAGGGA
TGCCGGGCTGCGGGTGATTCAGGTGGCGGAAACTATCGGTATTCGCGGGATGCTGGTCCATGCCCTGTCGGATGAAGCGC
GGGAGTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTT
CATGCCTGA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10691.22 Da Isoelectric Point: 8.5339
>AT220787 WP_013055003.1 NZ_CP085485:c2186393-2186112 [Priestia aryabhattai]
VSEASATTEILVRLPKNLVSELDLMVKQENGNRSDFIHQATKLYLRERKKRHIRESMRRGYMEMAKINLNIASEAFLAEY
EADHTVDRLVSGG
VSEASATTEILVRLPKNLVSELDLMVKQENGNRSDFIHQATKLYLRERKKRHIRESMRRGYMEMAKINLNIASEAFLAEY
EADHTVDRLVSGG
Download Length: 282 bp
>AT220787 NZ_CP117291:c4126937-4126644 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCCAGTCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGCATCAAGCCCGCCGAGCGCGATCTTATCGA
TCGGGCTGCAAAAGCCAGAGGGAAAAACTGCACAGACTTTGTGCTAGAAGCTGCCCGCGCCGCCGCCGAGGAAGCGCTGA
TCGAGCAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGCATTTCTGATCCGTCTGGATCAGGCTCCTGCGCCAAAC
GATGCGTTGCGTAAAACCATGCAGACTCCTGCACCGTGGGAGCAGGAAAAATGA
ATGCCAGTCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGCATCAAGCCCGCCGAGCGCGATCTTATCGA
TCGGGCTGCAAAAGCCAGAGGGAAAAACTGCACAGACTTTGTGCTAGAAGCTGCCCGCGCCGCCGCCGAGGAAGCGCTGA
TCGAGCAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGCATTTCTGATCCGTCTGGATCAGGCTCCTGCGCCAAAC
GATGCGTTGCGTAAAACCATGCAGACTCCTGCACCGTGGGAGCAGGAAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|