Detailed information of TA system TA220760

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2605226..2606790
• Replicon: chromosome
• Accession: NZ_CP085468
• Organism: Aeromonas caviae strain 71485

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A2S4TP05
• Locus tag: LEO80_RS12200
• Protein ID: WP_005329232.1
• Coordinates: 2605480..2606790 (+)
• Length: 437 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LEO80_RS12195
• Protein ID: WP_005329233.1
• Coordinates: 2605226..2605480 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LEO80_RS12170 (LEO80_12170)	2600775..2600776	-	2	WP_235714324.1	IS5-like element IS5 family transposase	-
LEO80_RS12175 (LEO80_12175)	2601711..2602163	-	453	WP_021140686.1	DUF2384 domain-containing protein	-
LEO80_RS12180 (LEO80_12180)	2602418..2603725	+	1308	WP_021140687.1	Fic family protein	-
LEO80_RS12185 (LEO80_12185)	2603804..2604055	+	252	WP_010674977.1	plasmid stabilization protein	-
LEO80_RS12190 (LEO80_12190)	2604476..2604724	-	249	WP_010674978.1	hypothetical protein	-
LEO80_RS12195 (LEO80_12195)	2605226..2605480	+	255	WP_005329233.1	helix-turn-helix domain-containing protein	Antitoxin
LEO80_RS12200 (LEO80_12200)	2605480..2606790	+	1311	WP_005329232.1	type II toxin-antitoxin system HipA family toxin	Toxin
LEO80_RS12210 (LEO80_12210)	2607748..2609922	+	2175	WP_227262793.1	catalase/peroxidase HPI	-
LEO80_RS12215 (LEO80_12215)	2610023..2610787	-	765	WP_227262794.1	DeoR/GlpR family DNA-binding transcription regulator	-
LEO80_RS12220 (LEO80_12220)	2610831..2611346	-	516	WP_227262795.1	HAD hydrolase family protein	-
LEO80_RS21725	2611407..2611535	-	129	WP_268884826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2595306..2606790	11484

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 437 a.a.
• Molecular weight: 49096.31 Da
• Isoelectric Point: 7.1717

>T220760 WP_005329232.1 NZ_CP085468:2605480-2606790 [Aeromonas caviae]
MASLTVYMNGYRVGTFTKATNGAHQFQYDESWVKLPGSRPISLSMPLRQQRYQGDEAYNFFDNLLPDNPEVRNRVVARYQ
ADSTQPFDLLSCIGQDSVGALQLVAQGRPVPDVKRIECKPLSDAELEQIMTSYQQGIPLGMVREEDDFRISIAGAQEKTA
LLYLDNRWCLPHAATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKALGLPVPHCFIMQVGKVKALAVERFDRR
YATDRSWIMRLPQEDFCQVLNVPSARKYESHGGPGIADIMTTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSMYPAFGGKGLHPRDAKLAMGLTATKGKKYAIEQIFPRHFYQTAKAIGFEQVQMEKIISELTDNL
DEVISIVRQQLPDTFPTEIADSILGGLSSKAQRLKR

Nucleotide

• Length: 1311 bp

>T220760 NZ_CP117287:c2104119-2103352 [Streptococcus dysgalactiae subsp. equisimilis]
ATGAAACTAGAAGAATTTAGTCAAGATAATTTTGAACAAGCCTCCAAACGACTCGTTCGTTCTTTAACTCGTGGAAAAAC
AACCTCATCTCAGCCTAAGGCTATTTTGCTCGGTGGACAGAGTGGTGCTGGGAAAACAACGATCCATCGAATTAAACAAA
GGGAATTTCAAGGTAATATCATTATTATTGATGGAGATAGTTATCGCTCTTTTCATCCGAACTACCTTGGCCTACAGGAA
AGGTATGGCAAAGATAGTGTGGATTATACCAAAGTATTCGCGGGACAAATGGTTGAATATCTTGTAGATGAGTTGAGTAA
AAAAGGTTATCATTTATTAATCGAGGGTACCTTGAGAACAACAGAAGTTCCCAAAAAAACTGCACAATTATTGACAACTA
AAGGTTACCAAGTCTCACTTGCAGTAATTGCGACCAAGCCAGAATTGTCCTATCTCAGTACCTTGATACGTTATGAAGAG
CTCCATGCTATAGACCCTAGTCAAGCTAGAGCGACTCCCAAAGAGCACCATGATGGAATTGTAGAACATTTAGTTGATAA
CTTACGAGAGTTAGAAAATGACAAAATTTTTAATCAAATTCAAATTTATCAAAGAGATCAATCGTGTATTTATGATTCGC
AAGTAGATCAAATCTCAGCAGCAGAAGTTTTACAAGAATGCCTCTTCGGAAAATGGAGTAAGGTGGAGGAAGAGATGTTG
AAGTTGGGACAGGAACGGTTGAAAGAGCTGGGGGAAATTGATAAGTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9271.66 Da
• Isoelectric Point: 9.1571

>AT220760 WP_005329233.1 NZ_CP085468:2605226-2605480 [Aeromonas caviae]
MKVTSAKQLSACLKDARLSQKLSQGKVAGKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIRPRTDPAENATPGW
KEEW

Nucleotide

• Length: 255 bp

>AT220760 NZ_CP117287:c2104595-2104119 [Streptococcus dysgalactiae subsp. equisimilis]
ATGATTGGAGAAAATATTAAAACGTTACGCAAGGCACATAATCTAACTCAGCCTGAGTTCGCAAAGATTGTTGGTATCTC
TCGAAATAGTCTGAGTCGTTATGAAAATGGGACAAGTCGAGTTTCGACAGAATTAATAGATCGTATCTGCAAGAAATTTA
ATGTTTCTTATATCGATATCGTAGGGGAGGAAAAAATGCTCACACCAGTAGAAGATTATCAGTTAACTCTGAAAATTGAA
GTGATTAAAGAACGAGGGGCGAATATCTTAGCGCAACTTTATCGTTTTCAAGATGAACAAGGAATTGCATTTGATGATAC
TTCTAATCCTTGGGTTCTAATGAGCGATGATTTGTCTGATTTAATTAACACGAAGATTTATCTTGTTGCAACTTTTGAGG
ATATAGAGCGATTTAATGGCTATTTGGATGGCATTGAACGTATGCTAGAACAAGCTACTCATCTGGTGGTGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A2S4TP05