Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-YefM
Location 2230378..2230880 Replicon chromosome
Accession NZ_CP085468
Organism Aeromonas caviae strain 71485

Toxin (Protein)


Gene name yoeB Uniprot ID Q5XQD8
Locus tag LEO80_RS10525 Protein ID WP_032492620.1
Coordinates 2230378..2230632 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1V0BEH6
Locus tag LEO80_RS10530 Protein ID WP_032492621.1
Coordinates 2230629..2230880 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LEO80_RS10505 (LEO80_10505) 2226757..2227317 - 561 WP_001161490.1 recombinase family protein -
LEO80_RS10510 (LEO80_10510) 2227654..2228667 - 1014 WP_000845048.1 class 1 integron integrase IntI1 -
LEO80_RS10515 (LEO80_10515) 2228914..2229702 + 789 Protein_2037 AadA family aminoglycoside 3''-O-nucleotidyltransferase -
LEO80_RS10520 (LEO80_10520) 2229751..2230305 + 555 WP_012695458.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase -
LEO80_RS10525 (LEO80_10525) 2230378..2230632 - 255 WP_032492620.1 Txe/YoeB family addiction module toxin Toxin
LEO80_RS10530 (LEO80_10530) 2230629..2230880 - 252 WP_032492621.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LEO80_RS10535 (LEO80_10535) 2231064..2231696 + 633 WP_000186237.1 type B-3 chloramphenicol O-acetyltransferase CatB3 -
LEO80_RS10540 (LEO80_10540) 2231853..2232200 + 348 WP_227263692.1 quaternary ammonium compound efflux SMR transporter QacE -
LEO80_RS10545 (LEO80_10545) 2232194..2233033 + 840 WP_000259031.1 sulfonamide-resistant dihydropteroate synthase Sul1 -
LEO80_RS10550 (LEO80_10550) 2233335..2234603 - 1269 WP_041205731.1 IS4-like element ISAeme3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island ant(3'')-Ii-aac(6')-IId / catB3 / sul1 / blaPER-3 / mph(A) / aph(6)-Id / aph(3'')-Ib - 2227654..2314678 87024
- inside IScluster/Tn ant(3'')-Ii-aac(6')-IId / catB3 / sul1 / blaPER-3 / mph(A) - 2223787..2254466 30679
- inside Integron - - 2227654..2231750 4096


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10272.81 Da        Isoelectric Point: 9.3585

>T220759 WP_032492620.1 NZ_CP085468:c2230632-2230378 [Aeromonas caviae]
MRLIFSDDAWEDYLFWQKQDRRMVDRINKLIKETTREPFSGVGKPEPLKHALAGYWSRRITDEHRMVYKVADDALWIVQL
KYHY

Download         Length: 255 bp

>T220759 NZ_CP117287:c892426-891581 [Streptococcus dysgalactiae subsp. equisimilis]
ATGAACAAAGCTAAATTAACAGCACTCTGTCATAAAATATCAAAGAATACTGGTTTAACCTTTAATTCCGTGATGACCTA
TTACTTCCTAGAAGTCATTTTGAAAAAATTAAGTCAAAGTTCTTATTCAAATCACTATATCTTCAAAGGAGGATTCCTAC
TGTCGAATGTCATCGGAGTTGAATCTCGTAGCACTGTTGATATTGACTTTTTATTCCATCAAATAACACTCTCAGAAGAA
ACTGTTAAACAGCAACTCAAGGAAATTTTAGCAGATTCCGAAGAAGGTATATCTTTTGTGATTCAATCAATCACAACTAT
TAAAGAAAGTGATGACTATGGTGGCTATCGAGCAACAATTTCGTGCCAACTTGAGAATATTAAACAAGTTATCCATTTGG
ATATTGCGACAGGTGATGTTGTAACTCCTCAGCCGATAACATACGACTATAAAGCTATTTTTGATGAAGACAATTTTCCA
ATCATTGCTTATACAATTGAAACAATTCTAGCTGAAAAACTCCAAACCATCTATTCACGAAACTTCTTGAACAGCAGAAG
CAAAGACTTTTACGATGTTTATATTCTTTCAAAATTGAAGAAAAAAGATATTGATTTCAATCAGTTAAAAAATGCTTGCC
AAAGAACTTTTTCCTATCGCGAAACTGAGCTCGATTTCGAAAAAATTATTGAACTACTCGAGAGATTCAAATCTGATCCT
ACTCAGAATCAACAATGGCAAAATTATTCAAAAAAATATAGTTATACAAAAGGAATTTCACTTGCAAATGTGCTTGATGA
GATGATTAGTCTTATTACAATTATTATTTCTACTGACTCTGATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9244.40 Da        Isoelectric Point: 4.7769

>AT220759 WP_032492621.1 NZ_CP085468:c2230880-2230629 [Aeromonas caviae]
MDAITYTHARANLAGTMDRVCNDHEPVIITRNGDQSVVILSLEDFQALEETAYLLRSPANAKRLFKSIEQLEAGRGQARE
LAE

Download         Length: 252 bp

>AT220759 NZ_CP117287:c893013-892423 [Streptococcus dysgalactiae subsp. equisimilis]
ATGTCAAAAAAAGAGATTCTACTCGATTTTATAGAAAAGAACAATGGCATTGTCACAAACAAAGATTGTAAAGCACTAGG
TATTCCAACAATATATCTGACAAGACTAGAGAAAGAAGGCATTATCTTCCGAGTTGAAAAAGGTATTTTCCTAACCCAAA
ACGGAGACTATGATGAATACTACTTCTTTCAATATCGTTTTCCTAAGGCTATTTTCTCTTATATTTCGGCACTGTATCTA
CAACAGTTTACAGATGAAATTCCACAATATTTTGATGTGACAGTTCCTAGAGGCTACCGCTTTAATACTCCTCCAGCTAA
TCTAAACATTCACTTTGTCTCTAAAGAATACAGCGAGCTGGGAATGACTACTGTACCTACTCCTATGGGAAACAACGTAA
GGGTATATGATTTTGAACGTATTATTTGTGATTTTGTAATACATCGAGAAAAGATTGATTCCGAACTCTTTGTCAAGACA
CTTCAATCTTATGGGAACTATCCTAAAAAAAATCTAGCAAAACTCTATGAATATGCGACAAAAATGAATACTTTAGAAAA
AGTTAAACAAACTCTGGAGGTTCTAATATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1V0BEH9

Antitoxin

Source ID Structure
AlphaFold DB A0A1V0BEH6

References