Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 277758..278397 Replicon chromosome
Accession NZ_CP085397
Organism Peribacillus frigoritolerans strain KF3

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag LHV56_RS01435 Protein ID WP_034306610.1
Coordinates 278047..278397 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag LHV56_RS01430 Protein ID WP_034306380.1
Coordinates 277758..278039 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHV56_RS01410 (LHV56_01420) 273895..274485 - 591 WP_053537118.1 rhomboid family intramembrane serine protease -
LHV56_RS01415 (LHV56_01425) 274593..274943 + 351 WP_053537119.1 holo-ACP synthase -
LHV56_RS01420 (LHV56_01430) 275187..276191 + 1005 WP_053537120.1 outer membrane lipoprotein carrier protein LolA -
LHV56_RS01425 (LHV56_01435) 276410..277597 + 1188 WP_252297071.1 alanine racemase -
LHV56_RS01430 (LHV56_01440) 277758..278039 + 282 WP_034306380.1 antitoxin EndoAI Antitoxin
LHV56_RS01435 (LHV56_01445) 278047..278397 + 351 WP_034306610.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LHV56_RS01440 (LHV56_01450) 278809..279636 + 828 WP_054398282.1 RsbT co-antagonist protein RsbRA -
LHV56_RS01445 (LHV56_01455) 279639..279995 + 357 WP_048682053.1 STAS domain-containing protein -
LHV56_RS01450 (LHV56_01460) 279999..280400 + 402 WP_053537122.1 anti-sigma regulatory factor -
LHV56_RS01455 (LHV56_01465) 280410..281420 + 1011 WP_252297072.1 PP2C family protein-serine/threonine phosphatase -
LHV56_RS01460 (LHV56_01470) 281480..281812 + 333 WP_034306369.1 anti-sigma factor antagonist -
LHV56_RS01465 (LHV56_01475) 281809..282282 + 474 WP_053537124.1 anti-sigma B factor RsbW -
LHV56_RS01470 (LHV56_01480) 282260..283048 + 789 WP_034306363.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12955.06 Da        Isoelectric Point: 7.2029

>T220742 WP_034306610.1 NZ_CP085397:278047-278397 [Peribacillus frigoritolerans]
IVVKRGDVYFADLSPVVGSEQGGTRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEINAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEPMMQKVNEALQISLGLIEF

Download         Length: 351 bp

>T220742 NZ_CP117267:c929517-929227 [Rhizobium rhododendri]
GTGATCGAAGTTCGGCAGACCTCTATTTTTGCGAATTGGCTAGATGCGCTCCGAGACGCGCAGGCGCGCCAACGCATCGT
CGTTCGCATCCGGCGGCTCGAACTCGGTAACCCTGGAGATATCAAGCCGGTCGGTGAAGGTGTCAGCGAAATGCGCATCC
CTCATGGCCCCGGCTACAGGCTCTATTTCACCCGATCCGGTGAGACGATCGTCATTCTTTTATGCGGCGGCGACAAGTCA
TCGCAGGCAAGGGACATCGCAATCGCCCGGCAATTGGCTAAGGAGATTTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10713.13 Da        Isoelectric Point: 5.9054

>AT220742 WP_034306380.1 NZ_CP085397:277758-278039 [Peribacillus frigoritolerans]
VSESSATREILIRLPQNFLTELDGYASEENVNRSEFIYRATKMYLRERKKKEFRESMKRGYIEMAAINLTIASEAFQAEF
EAGHCVERLVSGG

Download         Length: 282 bp

>AT220742 NZ_CP117267:c929226-928930 [Rhizobium rhododendri]
ATGCCCTTGGAAACCACCCGCTTTGACATCCAGGACCATTTGACCACACCGGCCGACCGCATGCTCTATCTCGAAGCCGC
TTTCGAGGACGGTGATCCGGCGCTCATCACCCAGGCCCTCGGCGACGTTGCCCGTGCTGCCGGCATGACGTCTGTCGCCA
AAGAAGCGGGCGTGACCCGGGAAGCACTCTATAAATCACTGAGCGAAGCCGGTGATCCGCGCTTGTCGACCTTTCTCGGC
GTGATCAAGGCGCTAGGATTGAAGGTGTCGATCTCGACGGATCAGAATGCGGCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References