Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3797726..3798560 Replicon chromosome
Accession NZ_CP085183
Organism Escherichia coli strain EC7518

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2X7CAN1
Locus tag LIN51_RS18465 Protein ID WP_039025883.1
Coordinates 3798183..3798560 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2X5LBZ2
Locus tag LIN51_RS18460 Protein ID WP_039025882.1
Coordinates 3797726..3798094 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN51_RS18435 (3794846) 3794846..3795664 + 819 WP_001598214.1 DUF932 domain-containing protein -
LIN51_RS18440 (3795756) 3795756..3796241 + 486 WP_001563926.1 antirestriction protein -
LIN51_RS18445 (3796257) 3796257..3796733 + 477 WP_227311694.1 RadC family protein -
LIN51_RS18450 (3796796) 3796796..3797017 + 222 WP_000692353.1 DUF987 domain-containing protein -
LIN51_RS18455 (3797032) 3797032..3797676 + 645 WP_039025881.1 hypothetical protein -
LIN51_RS18460 (3797726) 3797726..3798094 + 369 WP_039025882.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LIN51_RS18465 (3798183) 3798183..3798560 + 378 WP_039025883.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
LIN51_RS18470 (3798557) 3798557..3799045 + 489 Protein_3616 DUF5983 family protein -
LIN51_RS18475 (3799065) 3799065..3799262 + 198 WP_000772024.1 DUF957 domain-containing protein -
LIN51_RS18480 (3799359) 3799359..3800207 + 849 WP_039025884.1 DUF4942 domain-containing protein -
LIN51_RS18485 (3800300) 3800300..3801619 - 1320 WP_000144688.1 site-specific integrase -
LIN51_RS18490 (3801956) 3801956..3802294 - 339 Protein_3620 LysR substrate-binding domain-containing protein -
LIN51_RS18495 (3802345) 3802345..3803301 - 957 WP_000121326.1 molybdenum cofactor insertion chaperone PaoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14176.22 Da        Isoelectric Point: 7.8523

>T220550 WP_039025883.1 NZ_CP085183:3798183-3798560 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQLEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR

Download         Length: 378 bp

>T220550 NZ_CP117168:c4585109-4584687 [Serratia proteamaculans]
GTGGCCCAGTGGCGATGTGACGTCCGTATTTCCTGGCGCACCCAGTTACTTTCCCTGCTGACACATGGCGCACTGATCCT
GCTGATCCTGATTTCACCCTGGCCGGAAGGCTACGGGCCGATCTGGCTGGTGTTGCTGACGCTGGTGGTGTTTGAGTGCA
TTCGCAGCCAAAAGCGCATTGCGTCGCGGCAGGGCGAACTACGCCTGCTGGAAAACCAACGTCTGGGTTGGCACGGCCAG
GAATGGCAACTGGTGAAGCAGCCCTGGATGCCGCGTTACGGCATTCTGCTGACCTTGCAACCCGTGGGGGGCAAAAAGCG
CCGTCGACTGTGGCTGGCATCCGATGCCATGGCCAAAGCCGATTGGCGGCATCTGCGCCAGCAGTTGCTCTATCCGCCGG
CCAGTGATGACGAGGAACCCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13792.52 Da        Isoelectric Point: 5.9582

>AT220550 WP_039025882.1 NZ_CP085183:3797726-3798094 [Escherichia coli]
VSDTFHETNYPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT220550 NZ_CP117168:c4585356-4585090 [Serratia proteamaculans]
ATGGATATTAATAACAAAGCACGCATCCACTGGGCTTGTCGCCGTGGTATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAGTATGAATACGACCAGTTGAATGACACAGACAAAGCGCTGTTTATCCGCCTGCTGGAGTCCGACGATCCCGATC
TCTTCAACTGGCTGATGAATCATGGCGCTCCGCAGGACAGTGAACTGCAGAGAATGGTGACACTGATCCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X7CAN1

Antitoxin

Source ID Structure
AlphaFold DB A0A2X5LBZ2

References