Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 2898335..2899119 Replicon chromosome
Accession NZ_CP085143
Organism Halomonas sp. NyZ770

Toxin (Protein)


Gene name dhiT Uniprot ID -
Locus tag LG409_RS13455 Protein ID WP_081139058.1
Coordinates 2898850..2899119 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID -
Locus tag LG409_RS13450 Protein ID WP_227406877.1
Coordinates 2898335..2898856 (-) Length 174 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LG409_RS13415 (LG409_13415) 2894175..2894759 + 585 WP_096922495.1 manganese efflux pump MntP family protein -
LG409_RS13420 (LG409_13420) 2894830..2895711 - 882 WP_264477580.1 class A beta-lactamase -
LG409_RS13425 (LG409_13425) 2895767..2896219 - 453 WP_227406874.1 N-acetyltransferase -
LG409_RS13430 (LG409_13430) 2896227..2896649 - 423 WP_227406875.1 GFA family protein -
LG409_RS13435 (LG409_13435) 2896688..2897158 - 471 WP_193460799.1 GNAT family N-acetyltransferase -
LG409_RS13440 (LG409_13440) 2897182..2897709 - 528 WP_096922491.1 GNAT family N-acetyltransferase -
LG409_RS13445 (LG409_13445) 2897807..2898271 - 465 WP_227406876.1 OsmC family protein -
LG409_RS13450 (LG409_13450) 2898335..2898856 - 522 WP_227406877.1 DUF2442 domain-containing protein Antitoxin
LG409_RS13455 (LG409_13455) 2898850..2899119 - 270 WP_081139058.1 DUF4160 domain-containing protein Toxin
LG409_RS13460 (LG409_13460) 2899286..2900107 + 822 WP_227406878.1 aldo/keto reductase -
LG409_RS13465 (LG409_13465) 2900271..2900522 + 252 WP_227406879.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
LG409_RS13470 (LG409_13470) 2900519..2900773 + 255 WP_016914643.1 Txe/YoeB family addiction module toxin -
LG409_RS13475 (LG409_13475) 2901071..2901961 - 891 WP_189463938.1 DMT family transporter -
LG409_RS13480 (LG409_13480) 2902050..2902781 - 732 WP_227406880.1 AraC family transcriptional regulator -
LG409_RS13485 (LG409_13485) 2902897..2903073 - 177 Protein_2618 type II toxin-antitoxin system Phd/YefM family antitoxin -
LG409_RS13490 (LG409_13490) 2903215..2903658 - 444 WP_227406881.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Uncharacterized protein HI1420

(65-171)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10312.91 Da        Isoelectric Point: 6.7439

>T220515 WP_081139058.1 NZ_CP085143:c2899119-2898850 [Halomonas sp. NyZ770]
MPEIDALLGLSFCLYFFDNKQHKLPHLHVKYGSYELIIAIETGECLEGYLPNKQRKRAESHIFDHREQLMVMWHKAVNGE
NPGKLGDVC

Download         Length: 270 bp

>T220515 NZ_CP117053:c3809778-3809401 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGAGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19131.67 Da        Isoelectric Point: 6.7334

>AT220515 WP_227406877.1 NZ_CP085143:c2898856-2898335 [Halomonas sp. NyZ770]
MLKIVDVDVISGHALALTFSDGYFGRADLTAYFSKPPFSEIKDFKRFSLTPEGSLNWSGNELSAATLRAITKGEQKSTDV
FVNVQEMETVIKQASWESMKEGRADILQAAIRSYVEQFGHSQVIAKAGIKSRTSAYRSLKPETRPNFDTLVQLGHAVIEL
AQERAVSINESSI

Download         Length: 522 bp

>AT220515 NZ_CP117053:c3810236-3809868 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCAGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References