Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | DhiAT/- |
| Location | 2898335..2899119 | Replicon | chromosome |
| Accession | NZ_CP085143 | ||
| Organism | Halomonas sp. NyZ770 | ||
Toxin (Protein)
| Gene name | dhiT | Uniprot ID | - |
| Locus tag | LG409_RS13455 | Protein ID | WP_081139058.1 |
| Coordinates | 2898850..2899119 (-) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | dhiA | Uniprot ID | - |
| Locus tag | LG409_RS13450 | Protein ID | WP_227406877.1 |
| Coordinates | 2898335..2898856 (-) | Length | 174 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LG409_RS13415 (LG409_13415) | 2894175..2894759 | + | 585 | WP_096922495.1 | manganese efflux pump MntP family protein | - |
| LG409_RS13420 (LG409_13420) | 2894830..2895711 | - | 882 | WP_264477580.1 | class A beta-lactamase | - |
| LG409_RS13425 (LG409_13425) | 2895767..2896219 | - | 453 | WP_227406874.1 | N-acetyltransferase | - |
| LG409_RS13430 (LG409_13430) | 2896227..2896649 | - | 423 | WP_227406875.1 | GFA family protein | - |
| LG409_RS13435 (LG409_13435) | 2896688..2897158 | - | 471 | WP_193460799.1 | GNAT family N-acetyltransferase | - |
| LG409_RS13440 (LG409_13440) | 2897182..2897709 | - | 528 | WP_096922491.1 | GNAT family N-acetyltransferase | - |
| LG409_RS13445 (LG409_13445) | 2897807..2898271 | - | 465 | WP_227406876.1 | OsmC family protein | - |
| LG409_RS13450 (LG409_13450) | 2898335..2898856 | - | 522 | WP_227406877.1 | DUF2442 domain-containing protein | Antitoxin |
| LG409_RS13455 (LG409_13455) | 2898850..2899119 | - | 270 | WP_081139058.1 | DUF4160 domain-containing protein | Toxin |
| LG409_RS13460 (LG409_13460) | 2899286..2900107 | + | 822 | WP_227406878.1 | aldo/keto reductase | - |
| LG409_RS13465 (LG409_13465) | 2900271..2900522 | + | 252 | WP_227406879.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
| LG409_RS13470 (LG409_13470) | 2900519..2900773 | + | 255 | WP_016914643.1 | Txe/YoeB family addiction module toxin | - |
| LG409_RS13475 (LG409_13475) | 2901071..2901961 | - | 891 | WP_189463938.1 | DMT family transporter | - |
| LG409_RS13480 (LG409_13480) | 2902050..2902781 | - | 732 | WP_227406880.1 | AraC family transcriptional regulator | - |
| LG409_RS13485 (LG409_13485) | 2902897..2903073 | - | 177 | Protein_2618 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| LG409_RS13490 (LG409_13490) | 2903215..2903658 | - | 444 | WP_227406881.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10312.91 Da Isoelectric Point: 6.7439
>T220515 WP_081139058.1 NZ_CP085143:c2899119-2898850 [Halomonas sp. NyZ770]
MPEIDALLGLSFCLYFFDNKQHKLPHLHVKYGSYELIIAIETGECLEGYLPNKQRKRAESHIFDHREQLMVMWHKAVNGE
NPGKLGDVC
MPEIDALLGLSFCLYFFDNKQHKLPHLHVKYGSYELIIAIETGECLEGYLPNKQRKRAESHIFDHREQLMVMWHKAVNGE
NPGKLGDVC
Download Length: 270 bp
>T220515 NZ_CP117053:c3809778-3809401 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGAGGAAGCATCCGGAGGCGAAACAATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGAGGAAGCATCCGGAGGCGAAACAATGA
Antitoxin
Download Length: 174 a.a. Molecular weight: 19131.67 Da Isoelectric Point: 6.7334
>AT220515 WP_227406877.1 NZ_CP085143:c2898856-2898335 [Halomonas sp. NyZ770]
MLKIVDVDVISGHALALTFSDGYFGRADLTAYFSKPPFSEIKDFKRFSLTPEGSLNWSGNELSAATLRAITKGEQKSTDV
FVNVQEMETVIKQASWESMKEGRADILQAAIRSYVEQFGHSQVIAKAGIKSRTSAYRSLKPETRPNFDTLVQLGHAVIEL
AQERAVSINESSI
MLKIVDVDVISGHALALTFSDGYFGRADLTAYFSKPPFSEIKDFKRFSLTPEGSLNWSGNELSAATLRAITKGEQKSTDV
FVNVQEMETVIKQASWESMKEGRADILQAAIRSYVEQFGHSQVIAKAGIKSRTSAYRSLKPETRPNFDTLVQLGHAVIEL
AQERAVSINESSI
Download Length: 522 bp
>AT220515 NZ_CP117053:c3810236-3809868 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCAGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCAGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|