Detailed information of TA system TA219779

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2137433..2137658
• Replicon: chromosome
• Accession: NZ_CP084879
• Organism: Shigella flexneri strain CMCC51574

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: LGV73_RS10905
• Protein ID: WP_000813254.1
• Coordinates: 2137503..2137658 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2137433..2137491 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGV73_RS10865	2133431..2133600	+	170	Protein_2125	hypothetical protein	-
LGV73_RS10870	2133746..2134492	+	747	WP_128861108.1	ATP-binding protein	-
LGV73_RS10875	2134507..2134929	+	423	WP_001118167.1	DUF977 family protein	-
LGV73_RS10880	2134987..2135343	+	357	WP_005048249.1	hypothetical protein	-
LGV73_RS10885	2135436..2135654	+	219	WP_000256998.1	DUF4014 family protein	-
LGV73_RS10890	2135656..2136021	+	366	WP_001229298.1	HNH endonuclease signature motif containing protein	-
LGV73_RS10895	2136018..2136683	+	666	WP_000208062.1	hypothetical protein	-
LGV73_RS10900	2136683..2137048	+	366	WP_000610655.1	DUF551 domain-containing protein	-
-	2137433..2137491	-	59	-	-	Antitoxin
LGV73_RS10905	2137503..2137658	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
LGV73_RS10915	2138995..2139594	+	600	WP_000940329.1	DUF1367 family protein	-
LGV73_RS10920	2139594..2139884	+	291	WP_000228038.1	DUF1364 domain-containing protein	-
LGV73_RS10925	2139881..2140435	+	555	WP_000640143.1	DUF1133 family protein	-
LGV73_RS10930	2140588..2140761	+	174	WP_000504450.1	hypothetical protein	-
LGV73_RS10935	2140823..2141979	+	1157	WP_094081550.1	IS3-like element IS600 family transposase	-
LGV73_RS10940	2141972..2142532	+	561	WP_072075205.1	ORF6N domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	sitABCD	ipaH9.8	2131847..2223293	91446

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T219779 WP_000813254.1 NZ_CP084879:2137503-2137658 [Shigella flexneri]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T219779 NZ_CP116706:c249473-249138 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCCCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAATGACATAGAAAAACTTGAAGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAGAAATCAGCAATTATCACAGTACTAGAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAAGAGGAAGAGAATAGCGTTGTCATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin

Nucleotide

• Length: 59 bp

>AT219779 NZ_CP084879:c2137491-2137433 [Shigella flexneri]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATTTGTGAGACATAGATTGGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin