Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4087713..4088332 Replicon chromosome
Accession NZ_CP084871
Organism Klebsiella pneumoniae strain 04A025

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LGM00_RS20045 Protein ID WP_002892050.1
Coordinates 4088114..4088332 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LGM00_RS20040 Protein ID WP_002892066.1
Coordinates 4087713..4088087 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM00_RS20030 (4082865) 4082865..4084058 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LGM00_RS20035 (4084081) 4084081..4087227 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LGM00_RS20040 (4087713) 4087713..4088087 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LGM00_RS20045 (4088114) 4088114..4088332 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LGM00_RS20050 (4088491) 4088491..4089057 + 567 WP_002892030.1 maltose O-acetyltransferase -
LGM00_RS20055 (4089029) 4089029..4089169 - 141 WP_004147370.1 hypothetical protein -
LGM00_RS20060 (4089190) 4089190..4089660 + 471 WP_002892026.1 YlaC family protein -
LGM00_RS20065 (4089635) 4089635..4091086 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
LGM00_RS20070 (4091187) 4091187..4091885 + 699 WP_002892021.1 GNAT family protein -
LGM00_RS20075 (4091882) 4091882..4092022 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LGM00_RS20080 (4092022) 4092022..4092285 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T219704 WP_002892050.1 NZ_CP084871:4088114-4088332 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T219704 NZ_CP116604:287249-288025 [Streptococcus sp. HN38]
ATGAGATTGGAAGAATTTAGTGAGGTAGAGTTTCAGAAGGCCTTACAGCGAACCATTCGGGCTTTAACTCGAGGAAAGAC
GATTCCAGATCAACCGAAAGCCATTTTACTTGGAGGTCAGAGCGGAGCAGGTAAGACAACGATACATCGTATCAAGCAAA
AAGAATTTCAAGGCAATATCATTATCATCGATGGTGACAGCTACCGTTCTCAGCATCCCAATTACTTAGCCTTGCAAGAA
AAGTATGGCAAAGATAGCGTGGACTATACCAAGGGATTTGCAGGAAAGATGGTAGAACATCTGGTTGATGAACTCAGTAA
ACGTGGTTATCATTTGTTAATTGAAGGGACTTTGCGTACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAACTTCTA
AAGGTTACCAAGTTTCTTTAGCTATTATTGGTACCAAACCAGAACTGTCCTATCTCAGCACCTTGATTCGTTACGAAGAG
CTTTATGCCATCGATCCGACGCAGGCCAGAGCAACACCCAAAGACCACCATGATGGGATTGTAGAGAACTTGGTTGATAA
CCTAAGAGAGTTAGAAAGCGATAAGATCTTTGACCGCATTCAGATTTATCAAAGAGACAGGACTTGCATTTATGATTCTG
AAACTGATGATGGTTCAGCAGCAGAAGTTCTTCAAAACTGCCTTTTCGGAGATTGGAGTAAAGTAGAGGAAGAAATGATG
AAGGTTGGACGGGAACGGTTGAGAGAGATGAGTAAAAGTAATGAAAACGATGTATAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT219704 WP_002892066.1 NZ_CP084871:4087713-4088087 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT219704 NZ_CP116604:286773-287249 [Streptococcus sp. HN38]
ATGATTGGAGACAGCATCAAGTCACTACGTCGGACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTTGGTATTTC
ACGCAATAGCCTGAGTCGCTACGAAAATGGTACCAGCACTGTTTCAACTGAACTCATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGGGAGGATAAGATGCTAACACCTGTTGAAGATTACCAACTGACTTTAAAAATAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCTCAACTCTATCGATATCAGGATAGTCAAGGTATTGCTTTTGATGATGA
AACAAATCCTTGGATTTTGATGAGTGATGATTTGGCTGAATTGATCAATACGAAAATATACCTTGTCGATACTTTCGATG
AAATAGAGCGTTACAATGGCTATTTAGACGGTATCGAGCGGATGTTAGACATGGTGCATCATCGGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References