Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4800021..4800537 Replicon chromosome
Accession NZ_CP084852
Organism Klebsiella pneumoniae strain SB2390

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag LGM13_RS23300 Protein ID WP_004178374.1
Coordinates 4800021..4800305 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LGM13_RS23305 Protein ID WP_002886901.1
Coordinates 4800295..4800537 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM13_RS23275 (4795505) 4795505..4795768 - 264 WP_228985702.1 PTS sugar transporter subunit IIB -
LGM13_RS23280 (4795898) 4795898..4796071 + 174 WP_032408826.1 hypothetical protein -
LGM13_RS23285 (4796074) 4796074..4796817 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LGM13_RS23290 (4797174) 4797174..4799312 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LGM13_RS23295 (4799553) 4799553..4800017 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LGM13_RS23300 (4800021) 4800021..4800305 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGM13_RS23305 (4800295) 4800295..4800537 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LGM13_RS23310 (4800615) 4800615..4802525 - 1911 WP_004178373.1 PRD domain-containing protein -
LGM13_RS23315 (4802548) 4802548..4803702 - 1155 WP_004178372.1 lactonase family protein -
LGM13_RS23320 (4803769) 4803769..4804509 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T219570 WP_004178374.1 NZ_CP084852:c4800305-4800021 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T219570 NZ_CP116528:479743-480084 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT219570 WP_002886901.1 NZ_CP084852:c4800537-4800295 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT219570 NZ_CP116528:479513-479743 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References