Detailed information of TA system TA219509

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4788916..4790597
• Replicon: chromosome
• Accession: NZ_CP084829
• Organism: Klebsiella pneumoniae strain SB615

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: LGM17_RS23365
• Protein ID: WP_226617367.1
• Coordinates: 4788916..4789833 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: LGM17_RS23370
• Protein ID: WP_004177809.1
• Coordinates: 4789839..4790597 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGM17_RS23345 (4784222)	4784222..4785742	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
LGM17_RS23350 (4785739)	4785739..4786737	+	999	WP_004186549.1	ribose ABC transporter permease	-
LGM17_RS23355 (4786768)	4786768..4787709	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
LGM17_RS23360 (4787784)	4787784..4788791	+	1008	WP_004221949.1	carbohydrate kinase family protein	-
LGM17_RS23365 (4788916)	4788916..4789833	-	918	WP_226617367.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LGM17_RS23370 (4789839)	4789839..4790597	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
LGM17_RS23375 (4790683)	4790683..4791411	-	729	WP_002885152.1	response regulator transcription factor	-
LGM17_RS23380 (4791684)	4791684..4793831	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
LGM17_RS23385 (4793828)	4793828..4793971	-	144	WP_022631365.1	hypothetical protein	-
LGM17_RS23390 (4794525)	4794525..4795211	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34671.20 Da
• Isoelectric Point: 5.7799

>T219509 WP_226617367.1 NZ_CP084829:c4789833-4788916 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPVWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T219509 NZ_CP116480:3537463-3537636 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTAGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT219509 WP_004177809.1 NZ_CP084829:c4790597-4789839 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT219509 NZ_CP116480:3537139-3537435 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Antitoxin

• AlphaFold DB: A6TH05