Detailed information of TA system TA219459

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 1170789..1172470
• Replicon: chromosome
• Accession: NZ_CP084823
• Organism: Klebsiella pneumoniae strain T69

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: LGM19_RS05660
• Protein ID: WP_032458900.1
• Coordinates: 1171553..1172470 (+)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: LGM19_RS05655
• Protein ID: WP_004177809.1
• Coordinates: 1170789..1171547 (+)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGM19_RS05640 (1166639)	1166639..1167325	-	687	WP_004151733.1	tetratricopeptide repeat protein	-
LGM19_RS05645 (1167555)	1167555..1169702	-	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
LGM19_RS05650 (1169975)	1169975..1170703	+	729	WP_004177810.1	response regulator transcription factor	-
LGM19_RS05655 (1170789)	1170789..1171547	+	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
LGM19_RS05660 (1171553)	1171553..1172470	+	918	WP_032458900.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LGM19_RS05665 (1172595)	1172595..1173602	-	1008	WP_004221949.1	carbohydrate kinase family protein	-
LGM19_RS05670 (1173677)	1173677..1174618	-	942	WP_002885156.1	ABC transporter substrate-binding protein	-
LGM19_RS05675 (1174649)	1174649..1175647	-	999	WP_002885172.1	ribose ABC transporter permease	-
LGM19_RS05680 (1175644)	1175644..1177164	-	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34645.07 Da
• Isoelectric Point: 5.4707

>T219459 WP_032458900.1 NZ_CP084823:1171553-1172470 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPVFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T219459 NZ_CP116458:1697502-1697900 [Acidithiobacillus ferriphilus]
ATGCTCGATACCAATATGTGTATTTACTTGATAAAGCATCAGCCTGAGAAAGTCGCTCAACGTTTCGCTCAGTGCTATGT
AGGTGACGTAGTGATGTCGGCTATTACCTACGCAGAACTGGAATATGGCGTTGCCGTTTCCGCAGATCCTGATCGCGAAC
GGGCTAACCTTGCGGCGCTGACAGAAGACATCCCGGTGATCACTTTCGATGCACTGGCTGGCGTTGCCTATGGCCCGATC
CGGCAGGCAACCAGCGAAAGCAAGAGAGATGCGCTGGATAAGCTCATTGCCGCCCATGCCGTCGCGCTAGGCGTGACGAT
CGTTACCAACAACACAAGGGATTTTGCCAAATATCCCGGCGTCATGATCGAGAACTGGTTGTCATCCGGTGCGCAATAG

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT219459 WP_004177809.1 NZ_CP084823:1170789-1171547 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT219459 NZ_CP116458:1697254-1697490 [Acidithiobacillus ferriphilus]
ATGCACACCACTCGCGTTTTCAAAAACGGCAATTCGCAAGCAGTGCGAATCCCTGCCGATCTAGCCTATGAGCGCTCCGA
CATAGAAGTGGAAATCGAGCGGGAAGGCGACGAAATCCGCATTCGCCCCGCCCACCGCCCGCTAGCCGGCGTGCTGTCGA
AGTTTGCCCGGTTCTCCCCCAACTTTATGGCGGATGGTCGTGGCGACCAGGAACAAACCGAGAGAGACACGCTGTGA

Structures

Antitoxin

• AlphaFold DB: A6TH05