Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 293172..293803 Replicon chromosome
Accession NZ_CP084767
Organism Klebsiella variicola subsp. tropica strain CDC4241-71

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LGN97_RS01325 Protein ID WP_074387014.1
Coordinates 293172..293447 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LGN97_RS01330 Protein ID WP_022066422.1
Coordinates 293444..293803 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGN97_RS01305 (LGN97_01305) 288406..288741 + 336 WP_061153044.1 universal stress protein UspB -
LGN97_RS01310 (LGN97_01310) 288802..290298 - 1497 WP_061153045.1 inorganic phosphate transporter PitA -
LGN97_RS01315 (LGN97_01315) 290529..291722 + 1194 WP_074387012.1 NAD(P)/FAD-dependent oxidoreductase -
LGN97_RS01320 (LGN97_01320) 291762..292775 - 1014 WP_074387013.1 magnesium transporter -
LGN97_RS01325 (LGN97_01325) 293172..293447 + 276 WP_074387014.1 type II toxin-antitoxin system HicA family toxin Toxin
LGN97_RS01330 (LGN97_01330) 293444..293803 + 360 WP_022066422.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LGN97_RS01335 (LGN97_01335) 293831..294232 - 402 WP_048330886.1 nickel-responsive transcriptional regulator NikR -
LGN97_RS01340 (LGN97_01340) 294220..295011 - 792 WP_074387015.1 nickel import ATP-binding protein NikE -
LGN97_RS01345 (LGN97_01345) 295008..295772 - 765 WP_023340796.1 nickel import ATP-binding protein NikD -
LGN97_RS01350 (LGN97_01350) 295772..296605 - 834 WP_074387016.1 nickel ABC transporter permease subunit NikC -
LGN97_RS01355 (LGN97_01355) 296602..297546 - 945 WP_074387017.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10265.88 Da        Isoelectric Point: 10.3165

>T219327 WP_074387014.1 NZ_CP084767:293172-293447 [Klebsiella variicola subsp. tropica]
MDQQVLSLRNKQRHTLEQLFKIPVPQGIKWADIESLIKALGGEIKEGRGSRCKFLLNHSIASFHRPHPSPDTDKGAVESV
RDWLITIGVKP

Download         Length: 276 bp

>T219327 NZ_CP116297:c766204-765881 [Tenacibaculum finnmarkense]
TTGTATCCAAGTAGATACAGTATTATGTTCTTTATTGAGAAAACAACTGAATTTGACAAATGGCTGAAAAAGTTGAAAGA
CTTCAAAGCAAAAGCTAAAATTTTGTTCAGAATTCAAAAATTGGAATCTGACGAACATTTTGGAGATTGTAAAACTGTTG
GCGATGGAATTCGGGAAATGCGAATAAATTTTGCAAAAGGCTACAGAATTTACTTCAAAGAAAAAGATGGAAAAGTAATT
GTTCTGCTAATTGGTGGAGATAAATCAACACAACAAAAGGACATTACGAAAGCGAAAGAAATTTGGAAAAAATTAAATAA
ATAG

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13294.99 Da        Isoelectric Point: 4.4605

>AT219327 WP_022066422.1 NZ_CP084767:293444-293803 [Klebsiella variicola subsp. tropica]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQQEGEISLQEYLADCHEAGIEPYAHPEKLKT
FTLRYPESFGERLSSAAAEEQVSVNTWILETLNERLKQA

Download         Length: 360 bp

>AT219327 NZ_CP116297:c765877-765593 [Tenacibaculum finnmarkense]
ATGGAAACTTCAAGATTTGAAATAGCTGATTATTTGGAAAGCAAAGAAATGATTGCGGAATATCTTAACACAGTTTTGGA
AGAAGGTAATAATGCAGATGTAATTAATGCAATCGGGAATATTGCTAAAGCTATCGGGATGACAAAAATTGCAGAAGAAA
CAGGTTTAAGCAGACCGAGTTTGTACAAAGCGTTATCAGATGGAGCGAAACCTCAATTTGCAACAATTATGAAAGTATTA
AAAGCAATCGGAGGGCAAATACAAGTAAATCCAGCATCTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References