Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 738383..738907 Replicon chromosome
Accession NZ_CP084719
Organism Staphylococcus chromogenes strain 76ME

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LGV34_RS03495 Protein ID WP_103159488.1
Coordinates 738554..738907 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A3A0K2V6
Locus tag LGV34_RS03490 Protein ID WP_037577177.1
Coordinates 738383..738553 (+) Length 57 a.a.

Genomic Context

LGV34_RS03465LGV34_RS03470LGV34_RS03475LGV34_RS03480LGV34_RS03485LGV34_RS03490LGV34_RS03495LGV34_RS03500LGV34_RS03505LGV34_RS03510LGV34_RS03515
Location: 734231..734704 (474 bp)
Type: Others
Protein ID: WP_051605022.1
Location: 734697..736175 (1479 bp)
Type: Others
Protein ID: WP_268217046.1
Location: 736172..736687 (516 bp)
Type: Others
Protein ID: WP_051605021.1
Location: 736684..737034 (351 bp)
Type: Others
Protein ID: WP_037577181.1
Location: 737150..738298 (1149 bp)
Type: Others
Protein ID: WP_268217047.1
Location: 738383..738553 (171 bp)
Type: Antitoxin
Protein ID: WP_037577177.1
Location: 738554..738907 (354 bp)
Type: Toxin
Protein ID: WP_103159488.1
Location: 738971..739975 (1005 bp)
Type: Others
Protein ID: WP_268217048.1
Location: 740056..740382 (327 bp)
Type: Others
Protein ID: WP_037577172.1
Location: 740385..740864 (480 bp)
Type: Others
Protein ID: WP_037577169.1
Location: 740839..741609 (771 bp)
Type: Others
Protein ID: WP_037577167.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LGV34_RS03465 (LGV34_03465)734231..734704+474WP_051605022.1PH domain-containing protein-
LGV34_RS03470 (LGV34_03470)734697..736175+1479WP_268217046.1PH domain-containing protein-
LGV34_RS03475 (LGV34_03475)736172..736687+516WP_051605021.1PH domain-containing protein-
LGV34_RS03480 (LGV34_03480)736684..737034+351WP_037577181.1holo-ACP synthase-
LGV34_RS03485 (LGV34_03485)737150..738298+1149WP_268217047.1alanine racemase-
LGV34_RS03490 (LGV34_03490)738383..738553+171WP_037577177.1type II toxin-antitoxin system antitoxin MazEAntitoxin
LGV34_RS03495 (LGV34_03495)738554..738907+354WP_103159488.1type II toxin-antitoxin system PemK/MazF family toxinToxin
LGV34_RS03500 (LGV34_03500)738971..739975+1005WP_268217048.1PP2C family protein-serine/threonine phosphatase-
LGV34_RS03505 (LGV34_03505)740056..740382+327WP_037577172.1anti-sigma factor antagonist-
LGV34_RS03510 (LGV34_03510)740385..740864+480WP_037577169.1anti-sigma B factor RsbW-
LGV34_RS03515 (LGV34_03515)740839..741609+771WP_037577167.1RNA polymerase sigma factor SigB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13064.34 Da        Isoelectric Point: 10.5127

>T219225 WP_103159488.1 NZ_CP084719:738554-738907 [Staphylococcus chromogenes]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIDKKKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSDKKMKEVNAALGISLGLHMNQHK

Download         Length: 354 bp

>T219225 NZ_CP116214:c5246407-5246120 [Klebsiella michiganensis]
ATGCCAATGGAGTTTGAATGGGATGCGAACAAGGCAAGAAGTAATCTAAGAAAACATGGAATCCGGTTTGAAGAAGCGGT
GCTCGTCTTTGACGATCCCCGGCATCTTTCCCGACAGGATCGTTATGAGAATGGTGAATATCGCTGGCAAACTATCGGTC
TCGTTCATGGGGTCATTGTTATCATGGTTGCGCATTCGGTCCGTTTTGAAAGTGGAACAGAGGTCATTCGTATTATCAGC
GCCCGGAAGGCGGACAGCAAAGAGAGAAATCGTTATGAACATGGTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6328.01 Da        Isoelectric Point: 4.2313

>AT219225 WP_037577177.1 NZ_CP084719:738383-738553 [Staphylococcus chromogenes]
MSAFNQTRVKSLEQSLKEGYVQMADLNLSLATEAYFVECEACDCNESHLLSNHKDD

Download         Length: 171 bp

>AT219225 NZ_CP116214:c5246133-5245831 [Klebsiella michiganensis]
ATGAACATGGTTAAACATAAACGTGACAATCCGGATACGCTTACGGCTAAGCGAGACGATGAGCTTAAAGCGCTGGCCAA
CAAAACGGATGATGAAATCGATTATAGCGGTATTCCCGCCACAGACGACGCACAGTGGTCAGATGCCGTACGCGGTAAAT
TTTACCGACCGCTAAAAACTCAGGCTTCTGTCCGTATTGATGCCGATATTATGGAGTGGCTTAAACGTCCCGGGAAAGGT
TATCAAACTCGACTGAATGCGATCTTAAGAGAAGCGATGATTCGCGATCTTAACAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A3A0K2V6

References