Detailed information of TA system TA021908

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 1942861..1943531
• Replicon: chromosome
• Accession: NC_008781
• Organism: Polaromonas naphthalenivorans CJ2

Toxin (Protein)

• Gene name: vapB
• Uniprot ID: A1VNA5
• Locus tag: PNAP_RS09125
• Protein ID: WP_011801214.1
• Coordinates: 1943103..1943531 (+)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A1VNA4
• Locus tag: PNAP_RS09120
• Protein ID: WP_011801213.1
• Coordinates: 1942861..1943106 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PNAP_RS09115	1938768..1942790	+	4023	WP_011801212.1	phosphoribosylformylglycinamidine synthase	-
PNAP_RS09120	1942861..1943106	+	246	WP_011801213.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
PNAP_RS09125	1943103..1943531	+	429	WP_011801214.1	type II toxin-antitoxin system VapC family toxin	Toxin
PNAP_RS27605	1943648..1944217	-	570	WP_198140629.1	IS630 family transposase	-
PNAP_RS27610	1944186..1944602	-	417	WP_011801216.1	hypothetical protein	-
PNAP_RS09140	1945022..1945921	-	900	WP_011801217.1	D-hexose-6-phosphate mutarotase	-
PNAP_RS09145	1945960..1946649	-	690	WP_011801218.1	outer membrane beta-barrel protein	-
PNAP_RS09150	1946669..1948285	-	1617	WP_011801219.1	prolyl oligopeptidase family serine peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-128)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-66)

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15576.03 Da
• Isoelectric Point: 5.6598

>T21908 WP_011801214.1 NC_008781:1943103-1943531 [Polaromonas naphthalenivorans CJ2]
VKYLLDTCLLSELVKTSPEPAVLGWMAARKESELFVSAMTIAELHRGVARLPASRRRSSLSVWLEQLEAGFEERVLPFTC
DTAHVWANMCAQAESEGKPMAAFDSIIAATALAHGLCLVTRNVRDFAQAPVEVLNPWPGQLP

Nucleotide

• Length: 429 bp

>T21908 NC_008781:1943103-1943531 [Polaromonas naphthalenivorans CJ2]
GTGAAGTACCTGCTCGATACCTGTTTGCTGTCCGAGTTGGTCAAAACCAGCCCCGAGCCGGCCGTTCTTGGCTGGATGGC
TGCACGCAAGGAGTCCGAACTTTTCGTCAGCGCCATGACGATAGCCGAGCTTCACCGGGGCGTGGCCAGGCTCCCGGCTT
CGCGCCGCCGCAGCAGCCTGTCAGTGTGGCTTGAACAGCTAGAAGCGGGTTTTGAAGAGCGCGTACTGCCGTTCACCTGC
GACACCGCGCATGTCTGGGCCAATATGTGCGCGCAAGCCGAATCCGAAGGCAAGCCGATGGCCGCTTTCGATTCCATCAT
TGCTGCGACTGCGCTGGCGCACGGACTTTGCCTGGTGACGCGCAATGTCCGTGACTTTGCCCAGGCGCCTGTCGAAGTGT
TGAATCCTTGGCCGGGGCAGTTGCCTTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9021.24 Da
• Isoelectric Point: 5.7997

>AT21908 WP_011801213.1 NC_008781:1942861-1943106 [Polaromonas naphthalenivorans CJ2]
MHTWQLQEAKSRFSELVDLTLSEGPQLVTRRGQDAVVIVSAKDYRRMSGGAPSLLATLLNAPRGESLDLARSQEQIRDIE
L

Nucleotide

• Length: 246 bp

>AT21908 NC_008781:1942861-1943106 [Polaromonas naphthalenivorans CJ2]
ATGCATACATGGCAATTGCAGGAAGCGAAAAGCCGCTTCAGTGAACTGGTGGACCTCACGCTGAGTGAAGGCCCGCAGTT
GGTCACGCGGCGTGGACAAGATGCGGTGGTCATTGTGTCCGCGAAAGACTATCGCCGCATGAGTGGCGGCGCGCCTTCGT
TGCTTGCCACGCTGCTCAATGCGCCGCGCGGCGAATCCCTCGATCTGGCTCGCTCACAGGAACAGATCCGGGATATTGAG
TTGTGA

Structures

Toxin

• AlphaFold DB: A1VNA5

Antitoxin

• AlphaFold DB: A1VNA4