Detailed information of TA system TA021906

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 1301419..1302152
• Replicon: chromosome
• Accession: NC_008781
• Organism: Polaromonas naphthalenivorans CJ2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A1VLK0
• Locus tag: PNAP_RS06075
• Protein ID: WP_011800621.1
• Coordinates: 1301721..1302152 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapC
• Uniprot ID: A1VLJ9
• Locus tag: PNAP_RS06070
• Protein ID: WP_011800620.1
• Coordinates: 1301419..1301724 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PNAP_RS06070	1301419..1301724	+	306	WP_011800620.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
PNAP_RS06075	1301721..1302152	+	432	WP_011800621.1	type II toxin-antitoxin system VapC family toxin	Toxin
PNAP_RS06080	1302287..1303804	+	1518	WP_083758020.1	WG repeat-containing protein	-
PNAP_RS06085	1303784..1304353	-	570	WP_198140674.1	DUF4166 domain-containing protein	-
PNAP_RS06090	1304545..1305636	-	1092	WP_011800624.1	lytic murein transglycosylase B	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-118)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-67)

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15462.09 Da
• Isoelectric Point: 6.9533

>T21906 WP_011800621.1 NC_008781:1301721-1302152 [Polaromonas naphthalenivorans CJ2]
MMLLDTVVLSELRKARPNPGVVAYLKSQAAETVFLSALTIGEIEAGIERQRRVAPEFAGELARWLALMELQFAPFILPVT
PAIAKLWGRLCVQTGNKGIDNLIAATALCHNLTVVTRNVKDFELTGVRVFDPFSLPDAGGTAG

Nucleotide

• Length: 432 bp

>T21906 NC_008781:1301721-1302152 [Polaromonas naphthalenivorans CJ2]
ATGATGTTGTTGGACACGGTGGTGCTGTCCGAACTGCGCAAAGCCAGGCCCAACCCGGGCGTGGTGGCGTATTTGAAAAG
CCAGGCTGCCGAGACTGTTTTTCTAAGCGCCTTGACCATTGGCGAGATCGAAGCGGGCATTGAAAGGCAGCGCCGCGTGG
CGCCTGAATTTGCCGGGGAGCTTGCCCGGTGGCTGGCGTTGATGGAATTGCAATTTGCCCCTTTCATCCTGCCAGTAACC
CCGGCGATTGCCAAACTGTGGGGGCGGCTGTGCGTGCAAACCGGCAACAAGGGCATTGACAACCTGATCGCCGCCACGGC
CTTGTGCCACAACCTGACGGTGGTGACGCGCAATGTGAAGGATTTCGAGCTGACGGGTGTGCGGGTGTTTGATCCCTTCA
GCTTGCCGGACGCGGGCGGAACTGCCGGGTAA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 10972.39 Da
• Isoelectric Point: 7.3206

>AT21906 WP_011800620.1 NC_008781:1301419-1301724 [Polaromonas naphthalenivorans CJ2]
MPTPHSPTTASAWRLQDAKAQFSALVDNALRGVPQHVMRRGKPAVVVLSEQDFEALQRSAAGRADKPASFVEHLLAMPKA
PASEVADSPRQDVQPRDIDFS

Nucleotide

• Length: 306 bp

>AT21906 NC_008781:1301419-1301724 [Polaromonas naphthalenivorans CJ2]
ATGCCAACCCCACACTCCCCAACAACAGCATCAGCCTGGCGGCTGCAAGATGCCAAGGCGCAATTCAGCGCCCTGGTGGA
CAACGCCCTGCGTGGCGTGCCGCAGCATGTCATGCGGCGCGGCAAGCCGGCGGTGGTGGTGCTGTCGGAGCAGGACTTTG
AAGCTTTGCAGCGCAGCGCGGCCGGCAGGGCGGACAAGCCCGCGAGTTTTGTCGAGCATTTGCTGGCCATGCCCAAAGCG
CCCGCCAGCGAAGTGGCTGACTCGCCGCGTCAAGATGTGCAACCGCGCGATATTGATTTTTCATGA

Structures

Toxin

• AlphaFold DB: A1VLK0

Antitoxin

• AlphaFold DB: A1VLJ9