Detailed information of TA system TA218919

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3022196..3022865
• Replicon: chromosome
• Accession: NZ_CP084635
• Organism: Yersinia ruckeri strain 17Y0414

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A380QS17
• Locus tag: LGL86_RS14030
• Protein ID: WP_038241020.1
• Coordinates: 3022196..3022618 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: LGL86_RS14035
• Protein ID: WP_004719196.1
• Coordinates: 3022599..3022865 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGL86_RS14010 (LGL86_14040)	3018035..3019768	-	1734	WP_038276198.1	single-stranded-DNA-specific exonuclease RecJ	-
LGL86_RS14015 (LGL86_14045)	3019775..3020491	-	717	WP_004719192.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
LGL86_RS14020 (LGL86_14050)	3020523..3021422	-	900	WP_004719193.1	site-specific tyrosine recombinase XerD	-
LGL86_RS14025 (LGL86_14055)	3021530..3022048	+	519	WP_038241022.1	flavodoxin FldB	-
LGL86_RS14030 (LGL86_14060)	3022196..3022618	-	423	WP_038241020.1	protein YgfX	Toxin
LGL86_RS14035 (LGL86_14065)	3022599..3022865	-	267	WP_004719196.1	FAD assembly factor SdhE	Antitoxin
LGL86_RS14040 (LGL86_14070)	3023159..3024151	+	993	WP_096823598.1	tRNA-modifying protein YgfZ	-
LGL86_RS14045 (LGL86_14075)	3024290..3024955	-	666	WP_175537887.1	hemolysin III family protein	-
LGL86_RS14050 (LGL86_14080)	3025272..3025528	+	257	Protein_2723	HD domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16451.41 Da
• Isoelectric Point: 11.1478

>T218919 WP_038241020.1 NZ_CP084635:c3022618-3022196 [Yersinia ruckeri]
VAQWRCDLRVSWRTQLFSLLVHGVLVLLTLVVPWPDGFTPLWLILLTLVVFECIRSQKNITSRQGEIRLKAGNLLIWKWQ
EWTLVRPPWITRYGVLLSLQGAGSRRRKRIWLASDSMSEEKWRELCLILRHTFDSAAGRE

Nucleotide

• Length: 423 bp

>T218919 NZ_CP116124:c5526-5251 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGTCGCGGTTATTTGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAAATTAATGGCCAGACTATTTAT
GTATTGCGTCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10532.09 Da
• Isoelectric Point: 6.7185

>AT218919 WP_004719196.1 NZ_CP084635:c3022865-3022599 [Yersinia ruckeri]
MEIDNKARIHWACRRGMRELDISIMPFFEHEYDTLNDNDKRVFIRLLTSDDPDLFNWLMNHGEPQDSELKRMVKLIQTRN
KARGPVAM

Nucleotide

• Length: 267 bp

>AT218919 NZ_CP116124:c5810-5526 [Escherichia coli]
ATGCAAATGAAAAACAATGCCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGTTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
TCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Structures

Toxin

• AlphaFold DB: A0A380QS17